Detailed information of TA system TA134842

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2709271..2709850
• Replicon: chromosome
• Accession: NZ_CP042003
• Organism: Staphylococcus aureus strain B3-14B

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: FP480_RS13835
• Protein ID: WP_001025401.1
• Coordinates: 2709605..2709850 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2709271..2709636 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP480_RS13795	2706014..2706571	-	558	WP_145411552.1	DUF2815 family protein	-
FP480_RS13800	2706597..2707763	-	1167	WP_145411553.1	DUF2800 domain-containing protein	-
FP480_RS13805	2707760..2708122	-	363	WP_031775157.1	hypothetical protein	-
FP480_RS13810	2708137..2708460	-	324	WP_000174994.1	hypothetical protein	-
FP480_RS13815	2708539..2708700	-	162	WP_001285948.1	DUF1270 domain-containing protein	-
FP480_RS13820	2708713..2708976	-	264	WP_001124195.1	helix-turn-helix domain-containing protein	-
FP480_RS13825	2709001..2709216	-	216	WP_145411554.1	hypothetical protein	-
FP480_RS13830	2709271..2709636	+	366	WP_001128433.1	hypothetical protein	Antitoxin
FP480_RS13835	2709605..2709850	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
FP480_RS13840	2709906..2710115	+	210	WP_000642492.1	hypothetical protein	-
FP480_RS13845	2710105..2710248	-	144	WP_000939498.1	hypothetical protein	-
FP480_RS13850	2710315..2710695	+	381	WP_000773060.1	DUF2513 domain-containing protein	-
FP480_RS13855	2710682..2710879	-	198	WP_001148860.1	hypothetical protein	-
FP480_RS13860	2710949..2711161	+	213	WP_000362644.1	hypothetical protein	-
FP480_RS14940	2711202..2711351	-	150	WP_000771849.1	hypothetical protein	-
FP480_RS13865	2711435..2711626	-	192	WP_001115060.1	helix-turn-helix domain-containing protein	-
FP480_RS13870	2711787..2712116	+	330	WP_000429766.1	helix-turn-helix domain-containing protein	-
FP480_RS13875	2712129..2712590	+	462	WP_000525000.1	hypothetical protein	-
FP480_RS13880	2712608..2713042	+	435	WP_145411555.1	hypothetical protein	-
FP480_RS13885	2713070..2713465	+	396	WP_145411556.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2670311..2715212	44901

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T134842 WP_001025401.1 NZ_CP042003:c2709850-2709605 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T134842 NZ_CP042003:c2709850-2709605 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT134842 NZ_CP042003:2709271-2709636 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin