Detailed information of TA system TA134840

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 2530434..2530849
• Replicon: chromosome
• Accession: NZ_CP042003
• Organism: Staphylococcus aureus strain B3-14B

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A391LT45
• Locus tag: FP480_RS12730
• Protein ID: WP_001065108.1
• Coordinates: 2530604..2530849 (-)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FP480_RS14925
• Protein ID: WP_179207331.1
• Coordinates: 2530434..2530607 (-)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP480_RS12685	2526275..2527498	-	1224	WP_001037578.1	PBSX family phage terminase large subunit	-
FP480_RS12690	2527491..2527985	-	495	WP_000594088.1	terminase small subunit	-
FP480_RS12700	2528340..2528741	-	402	WP_000286968.1	hypothetical protein	-
FP480_RS12705	2528742..2528915	-	174	WP_002870008.1	transcriptional activator RinB	-
FP480_RS12710	2528908..2529144	-	237	WP_000483477.1	hypothetical protein	-
FP480_RS12715	2529169..2529405	-	237	WP_000195831.1	DUF1381 domain-containing protein	-
FP480_RS12720	2529442..2529975	-	534	WP_088524299.1	dUTPase	-
FP480_RS14920	2529990..2530151	-	162	WP_000889682.1	hypothetical protein	-
FP480_RS12725	2530152..2530433	-	282	Protein_2404	hypothetical protein	-
FP480_RS14925	2530434..2530607	-	174	WP_179207331.1	hypothetical protein	Antitoxin
FP480_RS12730	2530604..2530849	-	246	WP_001065108.1	DUF1024 family protein	Toxin
FP480_RS12735	2530864..2531112	-	249	WP_001126843.1	phi PVL orf 51-like protein	-
FP480_RS12740	2531113..2531484	-	372	WP_088524300.1	hypothetical protein	-
FP480_RS12745	2531485..2531670	-	186	WP_001187242.1	DUF3113 family protein	-
FP480_RS12750	2531675..2532079	-	405	WP_000049784.1	DUF1064 domain-containing protein	-
FP480_RS12755	2532076..2532501	-	426	WP_000451861.1	phage N-6-adenine-methyltransferase	-
FP480_RS12760	2532511..2532732	-	222	WP_001123688.1	DUF3269 family protein	-
FP480_RS14930	2532745..2532906	-	162	WP_000237153.1	hypothetical protein	-
FP480_RS12765	2532900..2533679	-	780	WP_061644672.1	ATP-binding protein	-
FP480_RS12770	2533689..2534459	-	771	WP_061843240.1	conserved phage C-terminal domain-containing protein	-
FP480_RS12775	2534505..2535164	+	660	WP_016028252.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2494895..2544953	50058

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1024 (1-78)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9067.05 Da
• Isoelectric Point: 4.1169

>T134840 WP_001065108.1 NZ_CP042003:c2530849-2530604 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILDGMTNAIQHSVKEGIELDEAVGIMAGQVIYKYEEEQG
K

Nucleotide

• Length: 246 bp

>T134840 NZ_CP042003:c2530849-2530604 [Staphylococcus aureus]
ATGAATAATCGTGAACAAATTGAACAATCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCGAGCATTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGAATTATGGCAGGTCAAGTTATCTATAAATATGAGGAGGAACAAGGA
AAATGA

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6482.32 Da
• Isoelectric Point: 4.2484

>AT134840 WP_179207331.1 NZ_CP042003:c2530607-2530434 [Staphylococcus aureus]
MSISLGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Nucleotide

• Length: 174 bp

>AT134840 NZ_CP042003:c2530607-2530434 [Staphylococcus aureus]
ATGAGTATTAGTTTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Structures

Toxin

• AlphaFold DB: A0A391LT45