Detailed information of TA system TA134837

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2078801..2079276
• Replicon: chromosome
• Accession: NZ_CP042003
• Organism: Staphylococcus aureus strain B3-14B

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: FP480_RS10270
• Protein ID: WP_000387655.1
• Coordinates: 2078801..2079103 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2079152..2079276 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP480_RS10240	2074002..2074316	+	315	WP_000274033.1	hypothetical protein	-
FP480_RS10245	2074322..2074461	-	140	Protein_1942	hypothetical protein	-
FP480_RS10255	2075144..2075386	-	243	WP_000725495.1	hypothetical protein	-
FP480_RS10260	2076250..2076990	-	741	WP_031796711.1	CPBP family intramembrane metalloprotease	-
FP480_RS10265	2077336..2078790	-	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
FP480_RS10270	2078801..2079103	-	303	WP_000387655.1	phage holin	Toxin
-	2079152..2079276	+	125	-	-	Antitoxin
FP480_RS10280	2079301..2079448	-	148	Protein_1948	putative holin-like toxin	-
FP480_RS10285	2079640..2079936	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
FP480_RS10290	2079994..2080281	-	288	WP_001040261.1	hypothetical protein	-
FP480_RS10295	2080328..2080480	-	153	WP_001153681.1	hypothetical protein	-
FP480_RS10300	2080470..2084255	-	3786	WP_145411537.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2074968..2118571	43603

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T134837 WP_000387655.1 NZ_CP042003:c2079103-2078801 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T134837 NZ_CP042003:c2079103-2078801 [Staphylococcus aureus]
ATGGAAGCAAAAGTAATAACAAGATATATTGTATTAATTTTAGCATTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
TCCGATACCAGTAGATGAAGAAAGTGTTTCATCGATTATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCTGAAAGTAAATATAGAAAAGCAACAGGT
CAAGCACCTGTCAAAGAAGTAATAGCACCTACAAATATGAACGATACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 125 bp

>AT134837 NZ_CP042003:2079152-2079276 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin