Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1203882..1204401 Replicon chromosome
Accession NZ_CP041994
Organism Streptococcus suis strain INT-01

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0K2E7Z7
Locus tag FPT06_RS06145 Protein ID WP_013730620.1
Coordinates 1204144..1204401 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K2E7Z9
Locus tag FPT06_RS06140 Protein ID WP_002939010.1
Coordinates 1203882..1204142 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPT06_RS06100 1199068..1199427 + 360 WP_013730625.1 ribonuclease P protein component -
FPT06_RS06105 1199411..1200223 + 813 WP_004194552.1 YidC/Oxa1 family membrane protein insertase -
FPT06_RS06110 1200243..1201238 + 996 WP_013730624.1 protein jag -
FPT06_RS06115 1201406..1201543 + 138 WP_002939016.1 50S ribosomal protein L34 -
FPT06_RS06120 1201651..1202433 + 783 WP_002939015.1 TatD family hydrolase -
FPT06_RS06125 1202417..1202986 + 570 WP_022540720.1 ribonuclease M5 -
FPT06_RS06130 1202979..1203347 + 369 WP_013730622.1 hypothetical protein -
FPT06_RS06135 1203351..1203806 + 456 WP_013730621.1 8-oxo-dGTP diphosphatase -
FPT06_RS06140 1203882..1204142 + 261 WP_002939010.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FPT06_RS06145 1204144..1204401 + 258 WP_013730620.1 Txe/YoeB family addiction module toxin Toxin
FPT06_RS06150 1204415..1204945 + 531 WP_009910909.1 DUF1697 domain-containing protein -
FPT06_RS06155 1204929..1205837 + 909 WP_074411269.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
FPT06_RS06160 1206200..1207930 + 1731 WP_013730619.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10346.86 Da        Isoelectric Point: 8.0279

>T134776 WP_013730620.1 NZ_CP041994:1204144-1204401 [Streptococcus suis]
MGIHFTDDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADRLCILSL
KDHYR

Download         Length: 258 bp

>T134776 NZ_CP041994:1204144-1204401 [Streptococcus suis]
ATGGGAATCCATTTTACAGACGACGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAGCGACATCCTTTTGAAGGCATTGCCAAACCAGAACCTTTGAAGTATGATTATCAAG
GTGCCTGGTCTCGGAGAATTGATGCGGAGAATCGGTTGATTTATATGGTGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9980.36 Da        Isoelectric Point: 5.7134

>AT134776 WP_002939010.1 NZ_CP041994:1203882-1204142 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAKVKTGQTQER
NLIEAD

Download         Length: 261 bp

>AT134776 NZ_CP041994:1203882-1204142 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2E7Z7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K2E7Z9

References