134746

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 43026..43296 Replicon plasmid pEC2_2
Accession NZ_CP041957
Organism Escherichia coli strain EC2

Toxin (Protein)


Gene name hok Uniprot ID P11895
Locus tag FOZ67_RS23845 Protein ID WP_001312861.1
Coordinates 43138..43296 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 43026..43089 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOZ67_RS23815 38737..39264 + 528 WP_000290834.1 single-stranded DNA-binding protein -
FOZ67_RS23820 39322..39555 + 234 WP_000006003.1 DUF905 family protein -
FOZ67_RS23825 39616..41639 + 2024 Protein_48 ParB/RepB/Spo0J family partition protein -
FOZ67_RS23830 41708..42142 + 435 WP_000845953.1 conjugation system SOS inhibitor PsiB -
FOZ67_RS23835 42139..42858 + 720 WP_001276217.1 plasmid SOS inhibition protein A -
- 42870..43094 + 225 NuclAT_0 - -
- 42870..43094 + 225 NuclAT_0 - -
- 42870..43094 + 225 NuclAT_0 - -
- 42870..43094 + 225 NuclAT_0 - -
FOZ67_RS23840 42879..43058 - 180 WP_001309233.1 hypothetical protein -
- 43026..43089 - 64 - - Antitoxin
FOZ67_RS23845 43138..43296 + 159 WP_001312861.1 type I toxin-antitoxin system Hok family toxin Toxin
FOZ67_RS25270 43534..43911 - 378 Protein_53 hypothetical protein -
FOZ67_RS23855 44211..44507 + 297 WP_001272251.1 hypothetical protein -
FOZ67_RS23860 44618..45439 + 822 WP_001234445.1 DUF945 domain-containing protein -
FOZ67_RS23865 45736..46338 - 603 WP_000243713.1 transglycosylase SLT domain-containing protein -
FOZ67_RS23870 46661..47044 + 384 WP_001354030.1 relaxosome protein TraM -
FOZ67_RS23875 47238..47909 + 672 WP_000283561.1 conjugal transfer transcriptional regulator TraJ -
FOZ67_RS23880 48046..48273 + 228 WP_000089263.1 conjugal transfer relaxosome protein TraY -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaNDM-5 / sul1 / qacE / aadA2 / dfrA12 - 1..83648 83648


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-48)


Sequences


Toxin        


Download         Length: 53 a.a.        Molecular weight: 6082.32 Da        Isoelectric Point: 9.2584

>T134746 WP_001312861.1 NZ_CP041957:43138-43296 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 159 bp

>T134746 NZ_CP041957:43138-43296 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 64 bp

>AT134746 NZ_CP041957:c43089-43026 [Escherichia coli]
GACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB P11895


Antitoxin

Download structure file

References