Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 43026..43296 | Replicon | plasmid pEC2_2 |
Accession | NZ_CP041957 | ||
Organism | Escherichia coli strain EC2 |
Toxin (Protein)
Gene name | hok | Uniprot ID | P11895 |
Locus tag | FOZ67_RS23845 | Protein ID | WP_001312861.1 |
Coordinates | 43138..43296 (+) | Length | 53 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 43026..43089 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOZ67_RS23815 | 38737..39264 | + | 528 | WP_000290834.1 | single-stranded DNA-binding protein | - |
FOZ67_RS23820 | 39322..39555 | + | 234 | WP_000006003.1 | DUF905 family protein | - |
FOZ67_RS23825 | 39616..41639 | + | 2024 | Protein_48 | ParB/RepB/Spo0J family partition protein | - |
FOZ67_RS23830 | 41708..42142 | + | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
FOZ67_RS23835 | 42139..42858 | + | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
- | 42870..43094 | + | 225 | NuclAT_0 | - | - |
- | 42870..43094 | + | 225 | NuclAT_0 | - | - |
- | 42870..43094 | + | 225 | NuclAT_0 | - | - |
- | 42870..43094 | + | 225 | NuclAT_0 | - | - |
FOZ67_RS23840 | 42879..43058 | - | 180 | WP_001309233.1 | hypothetical protein | - |
- | 43026..43089 | - | 64 | - | - | Antitoxin |
FOZ67_RS23845 | 43138..43296 | + | 159 | WP_001312861.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
FOZ67_RS25270 | 43534..43911 | - | 378 | Protein_53 | hypothetical protein | - |
FOZ67_RS23855 | 44211..44507 | + | 297 | WP_001272251.1 | hypothetical protein | - |
FOZ67_RS23860 | 44618..45439 | + | 822 | WP_001234445.1 | DUF945 domain-containing protein | - |
FOZ67_RS23865 | 45736..46338 | - | 603 | WP_000243713.1 | transglycosylase SLT domain-containing protein | - |
FOZ67_RS23870 | 46661..47044 | + | 384 | WP_001354030.1 | relaxosome protein TraM | - |
FOZ67_RS23875 | 47238..47909 | + | 672 | WP_000283561.1 | conjugal transfer transcriptional regulator TraJ | - |
FOZ67_RS23880 | 48046..48273 | + | 228 | WP_000089263.1 | conjugal transfer relaxosome protein TraY | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaNDM-5 / sul1 / qacE / aadA2 / dfrA12 | - | 1..83648 | 83648 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 6082.32 Da Isoelectric Point: 9.2584
>T134746 WP_001312861.1 NZ_CP041957:43138-43296 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 159 bp
>T134746 NZ_CP041957:43138-43296 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG
Antitoxin
Download Length: 64 bp
>AT134746 NZ_CP041957:c43089-43026 [Escherichia coli]
GACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCTT
GACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|