Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1164998..1165584 Replicon chromosome
Accession NZ_CP041933
Organism Pseudomonas sp. BJP69

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FPB55_RS05440 Protein ID WP_144187667.1
Coordinates 1165306..1165584 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag FPB55_RS05435 Protein ID WP_115293485.1
Coordinates 1164998..1165297 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPB55_RS05410 1160884..1161693 + 810 WP_178097497.1 tRNA cyclic N6-threonylcarbamoyladenosine(37) synthase TcdA -
FPB55_RS05415 1161765..1162175 - 411 WP_054890075.1 SufE family protein -
FPB55_RS05420 1162172..1163377 - 1206 WP_115293484.1 cysteine desulfurase -
FPB55_RS05425 1163459..1164493 - 1035 WP_144187665.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
FPB55_RS05430 1164525..1164872 - 348 WP_054881204.1 ArsC family reductase -
FPB55_RS05435 1164998..1165297 - 300 WP_115293485.1 HigA family addiction module antidote protein Antitoxin
FPB55_RS05440 1165306..1165584 - 279 WP_144187667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPB55_RS05445 1165833..1167479 + 1647 WP_054890073.1 Na+/H+ antiporter -
FPB55_RS05450 1168193..1169389 - 1197 WP_125855216.1 succinyldiaminopimelate transaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-90)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10441.82 Da        Isoelectric Point: 8.5480

>T134689 WP_144187667.1 NZ_CP041933:c1165584-1165306 [Pseudomonas sp. BJP69]
IIQRFSCVDTEALFVAGKTRRWSDIKSVAERKLAMLNAAIELRDLRSPPGNRLEALSGNRAGQHSIRVNDQWRLCFTWTD
SGPANVEITDYH

Download         Length: 279 bp

>T134689 NZ_CP041933:c1165584-1165306 [Pseudomonas sp. BJP69]
ATCATTCAACGCTTTAGTTGTGTCGACACGGAAGCACTCTTTGTTGCTGGAAAAACGCGACGTTGGTCAGATATCAAATC
AGTCGCGGAGCGCAAACTGGCCATGCTCAACGCCGCAATAGAGCTGCGAGACCTGCGATCGCCACCTGGCAACCGCCTCG
AGGCATTGAGCGGCAACCGTGCTGGTCAGCACAGCATTCGCGTCAATGACCAATGGCGCTTGTGCTTCACCTGGACCGAC
AGCGGGCCGGCCAACGTTGAAATTACCGATTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10884.56 Da        Isoelectric Point: 7.1676

>AT134689 WP_115293485.1 NZ_CP041933:c1165297-1164998 [Pseudomonas sp. BJP69]
MLKNGMRPIHPGEVLREDFQKEIGFSAAALARALGVATPTVNNILRERGGVSADMALRLSICLNTTPEFWLNLQTAFDLR
TAEQRHGEEIIGAVQRLVA

Download         Length: 300 bp

>AT134689 NZ_CP041933:c1165297-1164998 [Pseudomonas sp. BJP69]
ATGCTCAAGAACGGTATGCGTCCAATCCATCCCGGTGAAGTCCTGCGTGAGGACTTCCAGAAAGAAATAGGCTTCAGTGC
TGCGGCATTGGCCAGGGCGCTGGGCGTCGCCACTCCAACCGTCAACAATATCCTGCGCGAACGGGGCGGTGTTTCCGCCG
ATATGGCGCTGCGTCTGTCCATTTGCCTGAATACTACCCCCGAGTTCTGGCTCAACCTGCAGACCGCCTTCGATCTGCGC
ACCGCCGAACAGCGACACGGTGAAGAGATCATCGGGGCGGTACAGCGCCTGGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References