Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1234972..1235612 Replicon chromosome
Accession NZ_CP041927
Organism Klebsiella pneumoniae strain 18-2374

Toxin (Protein)


Gene name higB Uniprot ID W9BBY1
Locus tag FOM15_RS06265 Protein ID WP_016529833.1
Coordinates 1235265..1235612 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FOM15_RS06260 Protein ID WP_040181955.1
Coordinates 1234972..1235265 (-) Length 98 a.a.

Genomic Context


FOM15_RS06255FOM15_RS06240FOM15_RS06245FOM15_RS06250FOM15_RS06260FOM15_RS06265FOM15_RS06270FOM15_RS06275
Location: 1233394..1234902 (1509 bp)
Type: Others
Protein ID: WP_023301456.1
Location: 1231171..1231929 (759 bp)
Type: Others
Protein ID: WP_002920548.1
Location: 1231979..1232809 (831 bp)
Type: Others
Protein ID: WP_024622927.1
Location: 1232860..1233189 (330 bp)
Type: Others
Protein ID: WP_002920552.1
Location: 1234972..1235265 (294 bp)
Type: Antitoxin
Protein ID: WP_040181955.1
Location: 1235265..1235612 (348 bp)
Type: Toxin
Protein ID: WP_016529833.1
Location: 1235788..1238235 (2448 bp)
Type: Others
Protein ID: WP_002920561.1
Location: 1238253..1239686 (1434 bp)
Type: Others
Protein ID: WP_002920564.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FOM15_RS062401231171..1231929-759WP_002920548.1DeoR/GlpR family transcriptional regulator-
FOM15_RS062451231979..1232809-831WP_024622927.1rhomboid family intramembrane serine protease GlpG-
FOM15_RS062501232860..1233189-330WP_002920552.1thiosulfate sulfurtransferase GlpE-
FOM15_RS062551233394..1234902+1509WP_023301456.1glycerol-3-phosphate dehydrogenase-
FOM15_RS062601234972..1235265-294WP_040181955.1helix-turn-helix transcriptional regulatorAntitoxin
FOM15_RS062651235265..1235612-348WP_016529833.1type II toxin-antitoxin system RelE/ParE family toxinToxin
FOM15_RS062701235788..1238235-2448WP_002920561.1glycogen phosphorylase-
FOM15_RS062751238253..1239686-1434WP_002920564.1glycogen synthase GlgA-

Associated MGEs


Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-107)

Antitoxin

(9-87)


Sequences


Toxin        


Download         Length: 116 a.a.        Molecular weight: 13549.56 Da        Isoelectric Point: 5.6749

>T134668 WP_016529833.1 NZ_CP041927:c1235612-1235265 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T134668 NZ_CP041927:c1235612-1235265 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10539.30 Da        Isoelectric Point: 10.1464

>AT134668 WP_040181955.1 NZ_CP041927:c1235265-1234972 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV

Download         Length: 294 bp

>AT134668 NZ_CP041927:c1235265-1234972 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAAGTCTCGTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBW9BBY1


Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References