Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 1234972..1235612 | Replicon | chromosome |
Accession | NZ_CP041927 | ||
Organism | Klebsiella pneumoniae strain 18-2374 |
Toxin (Protein)
Gene name | higB | Uniprot ID | W9BBY1 |
Locus tag | FOM15_RS06265 | Protein ID | WP_016529833.1 |
Coordinates | 1235265..1235612 (-) | Length | 116 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | FOM15_RS06260 | Protein ID | WP_040181955.1 |
Coordinates | 1234972..1235265 (-) | Length | 98 a.a. |
Genomic Context
Location: 1233394..1234902 (1509 bp)
Type: Others
Protein ID: WP_023301456.1
Type: Others
Protein ID: WP_023301456.1
Location: 1231171..1231929 (759 bp)
Type: Others
Protein ID: WP_002920548.1
Type: Others
Protein ID: WP_002920548.1
Location: 1231979..1232809 (831 bp)
Type: Others
Protein ID: WP_024622927.1
Type: Others
Protein ID: WP_024622927.1
Location: 1232860..1233189 (330 bp)
Type: Others
Protein ID: WP_002920552.1
Type: Others
Protein ID: WP_002920552.1
Location: 1234972..1235265 (294 bp)
Type: Antitoxin
Protein ID: WP_040181955.1
Type: Antitoxin
Protein ID: WP_040181955.1
Location: 1235265..1235612 (348 bp)
Type: Toxin
Protein ID: WP_016529833.1
Type: Toxin
Protein ID: WP_016529833.1
Location: 1235788..1238235 (2448 bp)
Type: Others
Protein ID: WP_002920561.1
Type: Others
Protein ID: WP_002920561.1
Location: 1238253..1239686 (1434 bp)
Type: Others
Protein ID: WP_002920564.1
Type: Others
Protein ID: WP_002920564.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOM15_RS06240 | 1231171..1231929 | - | 759 | WP_002920548.1 | DeoR/GlpR family transcriptional regulator | - |
FOM15_RS06245 | 1231979..1232809 | - | 831 | WP_024622927.1 | rhomboid family intramembrane serine protease GlpG | - |
FOM15_RS06250 | 1232860..1233189 | - | 330 | WP_002920552.1 | thiosulfate sulfurtransferase GlpE | - |
FOM15_RS06255 | 1233394..1234902 | + | 1509 | WP_023301456.1 | glycerol-3-phosphate dehydrogenase | - |
FOM15_RS06260 | 1234972..1235265 | - | 294 | WP_040181955.1 | helix-turn-helix transcriptional regulator | Antitoxin |
FOM15_RS06265 | 1235265..1235612 | - | 348 | WP_016529833.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
FOM15_RS06270 | 1235788..1238235 | - | 2448 | WP_002920561.1 | glycogen phosphorylase | - |
FOM15_RS06275 | 1238253..1239686 | - | 1434 | WP_002920564.1 | glycogen synthase GlgA | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 13549.56 Da Isoelectric Point: 5.6749
>T134668 WP_016529833.1 NZ_CP041927:c1235612-1235265 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER
Download Length: 348 bp
>T134668 NZ_CP041927:c1235612-1235265 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10539.30 Da Isoelectric Point: 10.1464
>AT134668 WP_040181955.1 NZ_CP041927:c1235265-1234972 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKSLV
Download Length: 294 bp
>AT134668 NZ_CP041927:c1235265-1234972 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAAGTCTCGTTTAA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAAGTCTCGTTTAA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | W9BBY1 |
Antitoxin
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Source | ID | Structure |
---|---|---|
No matching records found |