Detailed information of TA system TA134633

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3964391..3964649
• Replicon: chromosome
• Accession: NZ_CP041919
• Organism: Escherichia coli strain Ec40743

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: FPV29_RS19200
• Protein ID: WP_000935262.1
• Coordinates: 3964440..3964649 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3964391..3964448 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPV29_RS24905	3959445..3960221	+	777	WP_168992569.1	fimbria/pilus outer membrane usher protein	-
FPV29_RS24910	3960396..3960770	+	375	WP_021521651.1	hypothetical protein	-
FPV29_RS19185	3960783..3961741	+	959	Protein_3699	fimbrial family protein	-
FPV29_RS19190	3961780..3962679	-	900	WP_001300855.1	transcriptional activator NhaR	-
FPV29_RS19195	3962745..3963911	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	3964391..3964448	-	58	-	-	Antitoxin
FPV29_RS19200	3964440..3964649	+	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
FPV29_RS19205	3964753..3965883	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
FPV29_RS19210	3965972..3967888	-	1917	WP_000516135.1	molecular chaperone DnaK	-
FPV29_RS19215	3968265..3968669	+	405	WP_000843559.1	DUF2541 family protein	-
FPV29_RS19220	3968695..3969408	+	714	WP_001102379.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T134633 WP_000935262.1 NZ_CP041919:3964440-3964649 [Escherichia coli]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T134633 NZ_CP041919:3964440-3964649 [Escherichia coli]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT134633 NZ_CP041919:c3964448-3964391 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin