Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1803383..1803885 Replicon chromosome
Accession NZ_CP041919
Organism Escherichia coli strain Ec40743

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag FPV29_RS08745 Protein ID WP_000767829.1
Coordinates 1803631..1803885 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag FPV29_RS08740 Protein ID WP_001259255.1
Coordinates 1803383..1803634 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPV29_RS08715 1798564..1799631 - 1068 WP_021579314.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
FPV29_RS08720 1799628..1800698 - 1071 WP_144114338.1 histidinol-phosphate transaminase -
FPV29_RS08725 1800695..1801999 - 1305 WP_001295420.1 histidinol dehydrogenase -
FPV29_RS08730 1802005..1802904 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
FPV29_RS08735 1803050..1803100 - 51 WP_001364200.1 his operon leader peptide -
FPV29_RS08740 1803383..1803634 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
FPV29_RS08745 1803631..1803885 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
FPV29_RS08750 1803968..1804792 + 825 WP_000754737.1 SDR family oxidoreductase -
FPV29_RS08755 1804838..1805767 + 930 WP_000803346.1 LysR family transcriptional regulator -
FPV29_RS08760 1805982..1806044 + 63 WP_010723108.1 membrane protein YoeI -
FPV29_RS08765 1806034..1807392 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
FPV29_RS08770 1807571..1808629 + 1059 WP_000492324.1 transport protein YeeE -
FPV29_RS08775 1808643..1808870 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T134619 WP_000767829.1 NZ_CP041919:1803631-1803885 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T134619 NZ_CP041919:1803631-1803885 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT134619 WP_001259255.1 NZ_CP041919:1803383-1803634 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT134619 NZ_CP041919:1803383-1803634 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References