Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2975372..2976020 Replicon chromosome
Accession NZ_CP041876
Organism Mycobacterium tuberculosis strain 1-0006P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ30_RS13900 Protein ID WP_003899414.1
Coordinates 2975372..2975695 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ30_RS13905 Protein ID WP_003899415.1
Coordinates 2975775..2976020 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ30_RS13870 2970695..2971693 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ30_RS13875 2971707..2972171 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ30_RS13880 2972159..2972410 + 252 WP_003908028.1 hypothetical protein -
FPJ30_RS13885 2972581..2974020 - 1440 WP_003901443.1 phage major capsid protein -
FPJ30_RS13890 2974028..2974561 - 534 WP_031666072.1 HK97 family phage prohead protease -
FPJ30_RS13895 2974714..2975205 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ30_RS13900 2975372..2975695 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ30_RS13905 2975775..2976020 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ30_RS13910 2976017..2977444 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ30_RS13915 2977446..2977838 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ30_RS13920 2977835..2978095 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ30_RS13925 2978112..2978474 - 363 WP_003900543.1 hypothetical protein -
FPJ30_RS13930 2978477..2979604 - 1128 WP_003899420.1 site-specific integrase -
FPJ30_RS13935 2979749..2979976 - 228 WP_003899421.1 hypothetical protein -
FPJ30_RS13940 2979973..2980362 - 390 WP_003899422.1 hypothetical protein -
FPJ30_RS13945 2980268..2980540 + 273 WP_003900544.1 hypothetical protein -
FPJ30_RS13950 2980639..2980872 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2970695..2979604 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T134601 WP_003899414.1 NZ_CP041876:c2975695-2975372 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T134601 NZ_CP041876:c2975695-2975372 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT134601 WP_003899415.1 NZ_CP041876:c2976020-2975775 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT134601 NZ_CP041876:c2976020-2975775 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References