Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2972888..2973536 Replicon chromosome
Accession NZ_CP041872
Organism Mycobacterium tuberculosis strain 1-0017P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ34_RS13905 Protein ID WP_003899414.1
Coordinates 2972888..2973211 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ34_RS13910 Protein ID WP_003899415.1
Coordinates 2973291..2973536 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ34_RS13875 2968211..2969209 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ34_RS13880 2969223..2969687 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ34_RS13885 2969675..2969926 + 252 WP_003908028.1 hypothetical protein -
FPJ34_RS13890 2970097..2971536 - 1440 WP_003901443.1 phage major capsid protein -
FPJ34_RS13895 2971544..2972077 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ34_RS13900 2972230..2972721 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ34_RS13905 2972888..2973211 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ34_RS13910 2973291..2973536 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ34_RS13915 2973533..2974960 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ34_RS13920 2974962..2975354 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ34_RS13925 2975351..2975611 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ34_RS13930 2975628..2975990 - 363 WP_003900543.1 hypothetical protein -
FPJ34_RS13935 2975993..2977120 - 1128 WP_003899420.1 site-specific integrase -
FPJ34_RS13940 2977265..2977492 - 228 WP_003899421.1 hypothetical protein -
FPJ34_RS13945 2977489..2977878 - 390 WP_003899422.1 hypothetical protein -
FPJ34_RS13950 2977784..2978056 + 273 WP_003900544.1 hypothetical protein -
FPJ34_RS13955 2978155..2978388 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2968211..2977120 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(12-54)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T134361 WP_003899414.1 NZ_CP041872:c2973211-2972888 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T134361 NZ_CP041872:c2973211-2972888 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT134361 WP_003899415.1 NZ_CP041872:c2973536-2973291 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT134361 NZ_CP041872:c2973536-2973291 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References