134242

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2975441..2976089 Replicon chromosome
Accession NZ_CP041870
Organism Mycobacterium tuberculosis strain 1-0023P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ36_RS13905 Protein ID WP_003899414.1
Coordinates 2975441..2975764 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ36_RS13910 Protein ID WP_003899415.1
Coordinates 2975844..2976089 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ36_RS13875 2970764..2971762 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ36_RS13880 2971776..2972240 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ36_RS13885 2972228..2972479 + 252 WP_003908028.1 hypothetical protein -
FPJ36_RS13890 2972650..2974089 - 1440 WP_003901443.1 phage major capsid protein -
FPJ36_RS13895 2974097..2974630 - 534 WP_031666072.1 HK97 family phage prohead protease -
FPJ36_RS13900 2974783..2975274 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ36_RS13905 2975441..2975764 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ36_RS13910 2975844..2976089 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ36_RS13915 2976086..2977513 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ36_RS13920 2977515..2977907 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ36_RS13925 2977904..2978164 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ36_RS13930 2978181..2978543 - 363 WP_003900543.1 hypothetical protein -
FPJ36_RS13935 2978546..2979673 - 1128 WP_003899420.1 site-specific integrase -
FPJ36_RS13940 2979818..2980045 - 228 WP_003899421.1 hypothetical protein -
FPJ36_RS13945 2980042..2980431 - 390 WP_003899422.1 hypothetical protein -
FPJ36_RS13950 2980337..2980609 + 273 WP_003900544.1 hypothetical protein -
FPJ36_RS13955 2980708..2980941 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2970764..2979673 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T134242 WP_003899414.1 NZ_CP041870:c2975764-2975441 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T134242 NZ_CP041870:c2975764-2975441 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT134242 WP_003899415.1 NZ_CP041870:c2976089-2975844 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT134242 NZ_CP041870:c2976089-2975844 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References