Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2956730..2957378 Replicon chromosome
Accession NZ_CP041864
Organism Mycobacterium tuberculosis strain 1-0044P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ42_RS13835 Protein ID WP_003899414.1
Coordinates 2956730..2957053 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ42_RS13840 Protein ID WP_003899415.1
Coordinates 2957133..2957378 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ42_RS13805 2952053..2953051 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ42_RS13810 2953065..2953529 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ42_RS13815 2953517..2953768 + 252 WP_003908028.1 hypothetical protein -
FPJ42_RS13820 2953939..2955378 - 1440 WP_003899411.1 phage major capsid protein -
FPJ42_RS13825 2955386..2955919 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ42_RS13830 2956072..2956563 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ42_RS13835 2956730..2957053 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ42_RS13840 2957133..2957378 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ42_RS13845 2957375..2958802 - 1428 WP_031654718.1 DUF3631 domain-containing protein -
FPJ42_RS13850 2958804..2959196 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ42_RS13855 2959193..2959453 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ42_RS13860 2959470..2959832 - 363 WP_003900543.1 hypothetical protein -
FPJ42_RS13865 2959835..2960962 - 1128 WP_003899420.1 site-specific integrase -
FPJ42_RS13870 2961107..2961334 - 228 WP_003899421.1 hypothetical protein -
FPJ42_RS13875 2961331..2961720 - 390 WP_003899422.1 hypothetical protein -
FPJ42_RS13880 2961626..2961898 + 273 WP_003900544.1 hypothetical protein -
FPJ42_RS13885 2961997..2962230 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2952053..2960962 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T133885 WP_003899414.1 NZ_CP041864:c2957053-2956730 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T133885 NZ_CP041864:c2957053-2956730 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT133885 WP_003899415.1 NZ_CP041864:c2957378-2957133 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT133885 NZ_CP041864:c2957378-2957133 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References