133869

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2186004..2186872 Replicon chromosome
Accession NZ_CP041864
Organism Mycobacterium tuberculosis strain 1-0044P6C4

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag FPJ42_RS10120 Protein ID WP_010886136.1
Coordinates 2186004..2186381 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag FPJ42_RS10125 Protein ID WP_003409886.1
Coordinates 2186423..2186872 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ42_RS10070 2181345..2181527 - 183 WP_003409870.1 hypothetical protein -
FPJ42_RS10075 2181641..2181991 - 351 WP_003899096.1 hypothetical protein -
FPJ42_RS10080 2182002..2182481 - 480 Protein_1991 hypothetical protein -
FPJ42_RS10085 2182530..2183791 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FPJ42_RS10090 2183834..2184262 - 429 Protein_1993 hypothetical protein -
FPJ42_RS10095 2184283..2184474 - 192 WP_003409876.1 hypothetical protein -
FPJ42_RS10100 2184475..2184771 - 297 WP_003409877.1 hypothetical protein -
FPJ42_RS10105 2185011..2185226 + 216 WP_003409878.1 antitoxin -
FPJ42_RS10110 2185223..2185534 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ42_RS10115 2185508..2186029 - 522 WP_003904745.1 hypothetical protein -
FPJ42_RS10120 2186004..2186381 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
FPJ42_RS10125 2186423..2186872 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
FPJ42_RS10130 2186869..2187414 + 546 WP_003409891.1 SecB-like chaperone -
FPJ42_RS10135 2187303..2187917 - 615 WP_003901296.1 hypothetical protein -
FPJ42_RS10140 2187966..2188262 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPJ42_RS10145 2188259..2188510 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
FPJ42_RS10150 2188497..2188991 + 495 WP_003899099.1 hypothetical protein -
FPJ42_RS10155 2189151..2189558 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ42_RS10160 2189562..2189834 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ42_RS10165 2189867..2191087 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T133869 WP_010886136.1 NZ_CP041864:2186004-2186381 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T133869 NZ_CP041864:2186004-2186381 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT133869 WP_003409886.1 NZ_CP041864:2186423-2186872 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT133869 NZ_CP041864:2186423-2186872 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References