Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2992675..2993323 Replicon chromosome
Accession NZ_CP041862
Organism Mycobacterium tuberculosis strain 1-0047P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ44_RS13970 Protein ID WP_003899414.1
Coordinates 2992675..2992998 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ44_RS13975 Protein ID WP_003899415.1
Coordinates 2993078..2993323 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ44_RS13940 2987998..2988996 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ44_RS13945 2989010..2989474 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ44_RS13950 2989462..2989713 + 252 WP_003908028.1 hypothetical protein -
FPJ44_RS13955 2989884..2991323 - 1440 WP_003901443.1 phage major capsid protein -
FPJ44_RS13960 2991331..2991864 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ44_RS13965 2992017..2992508 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ44_RS13970 2992675..2992998 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ44_RS13975 2993078..2993323 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ44_RS13980 2993320..2994747 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ44_RS13985 2994749..2995141 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ44_RS13990 2995138..2995398 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ44_RS13995 2995415..2995777 - 363 WP_003900543.1 hypothetical protein -
FPJ44_RS14000 2995780..2996907 - 1128 WP_003899420.1 site-specific integrase -
FPJ44_RS14005 2997052..2997279 - 228 WP_003899421.1 hypothetical protein -
FPJ44_RS14010 2997276..2997665 - 390 WP_003899422.1 hypothetical protein -
FPJ44_RS14015 2997571..2997843 + 273 WP_003900544.1 hypothetical protein -
FPJ44_RS14020 2997942..2998175 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2987998..2996907 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T133764 WP_003899414.1 NZ_CP041862:c2992998-2992675 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T133764 NZ_CP041862:c2992998-2992675 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT133764 WP_003899415.1 NZ_CP041862:c2993323-2993078 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT133764 NZ_CP041862:c2993323-2993078 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References