Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2972239..2972887 Replicon chromosome
Accession NZ_CP041858
Organism Mycobacterium tuberculosis strain 1-0064P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ48_RS13890 Protein ID WP_003899414.1
Coordinates 2972239..2972562 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ48_RS13895 Protein ID WP_003899415.1
Coordinates 2972642..2972887 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ48_RS13860 2967561..2968559 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ48_RS13865 2968573..2969037 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ48_RS13870 2969025..2969276 + 252 WP_003908028.1 hypothetical protein -
FPJ48_RS13875 2969447..2970886 - 1440 WP_003901443.1 phage major capsid protein -
FPJ48_RS13880 2970894..2971427 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ48_RS13885 2971580..2972071 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ48_RS13890 2972239..2972562 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ48_RS13895 2972642..2972887 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ48_RS13900 2972884..2974311 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ48_RS13905 2974313..2974705 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ48_RS13910 2974702..2974962 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ48_RS13915 2974979..2975341 - 363 WP_003900543.1 hypothetical protein -
FPJ48_RS13920 2975344..2976471 - 1128 WP_003899420.1 site-specific integrase -
FPJ48_RS13925 2976616..2976843 - 228 WP_003899421.1 hypothetical protein -
FPJ48_RS13930 2976840..2977229 - 390 WP_003899422.1 hypothetical protein -
FPJ48_RS13935 2977135..2977407 + 273 WP_003900544.1 hypothetical protein -
FPJ48_RS13940 2977506..2977739 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2967561..2976471 8910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T133525 WP_003899414.1 NZ_CP041858:c2972562-2972239 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T133525 NZ_CP041858:c2972562-2972239 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT133525 WP_003899415.1 NZ_CP041858:c2972887-2972642 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT133525 NZ_CP041858:c2972887-2972642 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References