133465

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2969503..2970151 Replicon chromosome
Accession NZ_CP041857
Organism Mycobacterium tuberculosis strain 1-0069P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ50_RS13850 Protein ID WP_003899414.1
Coordinates 2969503..2969826 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ50_RS13855 Protein ID WP_003899415.1
Coordinates 2969906..2970151 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ50_RS13820 2964826..2965824 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ50_RS13825 2965838..2966302 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ50_RS13830 2966290..2966541 + 252 WP_003908028.1 hypothetical protein -
FPJ50_RS13835 2966712..2968151 - 1440 WP_003901443.1 phage major capsid protein -
FPJ50_RS13840 2968159..2968692 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ50_RS13845 2968845..2969336 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ50_RS13850 2969503..2969826 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ50_RS13855 2969906..2970151 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ50_RS13860 2970148..2971575 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ50_RS13865 2971577..2971969 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ50_RS13870 2971966..2972226 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ50_RS13875 2972243..2972605 - 363 WP_003900543.1 hypothetical protein -
FPJ50_RS13880 2972608..2973735 - 1128 WP_003899420.1 site-specific integrase -
FPJ50_RS13885 2973880..2974107 - 228 WP_003899421.1 hypothetical protein -
FPJ50_RS13890 2974104..2974493 - 390 WP_003899422.1 hypothetical protein -
FPJ50_RS13895 2974399..2974671 + 273 WP_003900544.1 hypothetical protein -
FPJ50_RS13900 2974770..2975003 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2964826..2973735 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(159-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T133465 WP_003899414.1 NZ_CP041857:c2969826-2969503 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T133465 NZ_CP041857:c2969826-2969503 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT133465 WP_003899415.1 NZ_CP041857:c2970151-2969906 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT133465 NZ_CP041857:c2970151-2969906 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References