Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2969507..2970155 Replicon chromosome
Accession NZ_CP041856
Organism Mycobacterium tuberculosis strain 1-0071P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ51_RS13855 Protein ID WP_003899414.1
Coordinates 2969507..2969830 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ51_RS13860 Protein ID WP_003899415.1
Coordinates 2969910..2970155 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ51_RS13825 2964830..2965828 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ51_RS13830 2965842..2966306 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ51_RS13835 2966294..2966545 + 252 WP_003908028.1 hypothetical protein -
FPJ51_RS13840 2966716..2968155 - 1440 WP_003901443.1 phage major capsid protein -
FPJ51_RS13845 2968163..2968696 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ51_RS13850 2968849..2969340 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ51_RS13855 2969507..2969830 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ51_RS13860 2969910..2970155 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ51_RS13865 2970152..2971579 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ51_RS13870 2971581..2971973 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ51_RS13875 2971970..2972230 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ51_RS13880 2972247..2972609 - 363 WP_003900543.1 hypothetical protein -
FPJ51_RS13885 2972612..2973739 - 1128 WP_003899420.1 site-specific integrase -
FPJ51_RS13890 2973884..2974111 - 228 WP_003899421.1 hypothetical protein -
FPJ51_RS13895 2974108..2974497 - 390 WP_003899422.1 hypothetical protein -
FPJ51_RS13900 2974403..2974675 + 273 WP_003900544.1 hypothetical protein -
FPJ51_RS13905 2974774..2975007 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2964830..2973739 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-107)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T133405 WP_003899414.1 NZ_CP041856:c2969830-2969507 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T133405 NZ_CP041856:c2969830-2969507 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT133405 WP_003899415.1 NZ_CP041856:c2970155-2969910 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT133405 NZ_CP041856:c2970155-2969910 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References