Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2972889..2973537 Replicon chromosome
Accession NZ_CP041855
Organism Mycobacterium tuberculosis strain 1-0084P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ53_RS13905 Protein ID WP_003899414.1
Coordinates 2972889..2973212 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ53_RS13910 Protein ID WP_003899415.1
Coordinates 2973292..2973537 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ53_RS13875 2968212..2969210 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ53_RS13880 2969224..2969688 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ53_RS13885 2969676..2969927 + 252 WP_003908028.1 hypothetical protein -
FPJ53_RS13890 2970098..2971537 - 1440 WP_003901443.1 phage major capsid protein -
FPJ53_RS13895 2971545..2972078 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ53_RS13900 2972231..2972722 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ53_RS13905 2972889..2973212 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ53_RS13910 2973292..2973537 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ53_RS13915 2973534..2974961 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ53_RS13920 2974963..2975355 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ53_RS13925 2975352..2975612 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ53_RS13930 2975629..2975991 - 363 WP_003900543.1 hypothetical protein -
FPJ53_RS13935 2975994..2977121 - 1128 WP_003899420.1 site-specific integrase -
FPJ53_RS13940 2977266..2977493 - 228 WP_003899421.1 hypothetical protein -
FPJ53_RS13945 2977490..2977879 - 390 WP_003899422.1 hypothetical protein -
FPJ53_RS13950 2977785..2978057 + 273 WP_003900544.1 hypothetical protein -
FPJ53_RS13955 2978156..2978389 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2968212..2977121 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T133345 WP_003899414.1 NZ_CP041855:c2973212-2972889 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T133345 NZ_CP041855:c2973212-2972889 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT133345 WP_003899415.1 NZ_CP041855:c2973537-2973292 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT133345 NZ_CP041855:c2973537-2973292 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References