Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2193019..2193887 Replicon chromosome
Accession NZ_CP041854
Organism Mycobacterium tuberculosis strain 1-0102P6C4

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag FPJ54_RS10150 Protein ID WP_010886136.1
Coordinates 2193019..2193396 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag FPJ54_RS10155 Protein ID WP_003409886.1
Coordinates 2193438..2193887 (+) Length 150 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ54_RS10100 2188808..2189260 - 453 WP_003899095.1 lipoprotein -
FPJ54_RS10105 2189324..2189725 + 402 WP_003409869.1 hypothetical protein -
FPJ54_RS10110 2189718..2189900 - 183 WP_003409870.1 hypothetical protein -
FPJ54_RS10115 2190014..2190364 - 351 WP_003409871.1 hypothetical protein -
FPJ54_RS10120 2190375..2191277 - 903 WP_003899097.1 hypothetical protein -
FPJ54_RS10125 2191298..2191489 - 192 WP_003409876.1 hypothetical protein -
FPJ54_RS10130 2191490..2191786 - 297 WP_003409877.1 hypothetical protein -
FPJ54_RS10135 2192026..2192241 + 216 WP_003409878.1 antitoxin -
FPJ54_RS10140 2192238..2192549 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ54_RS10145 2192523..2193044 - 522 WP_003904745.1 hypothetical protein -
FPJ54_RS10150 2193019..2193396 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
FPJ54_RS10155 2193438..2193887 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
FPJ54_RS10160 2193884..2194429 + 546 WP_003409891.1 SecB-like chaperone -
FPJ54_RS10165 2194318..2194932 - 615 WP_003901296.1 hypothetical protein -
FPJ54_RS10170 2194981..2195277 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPJ54_RS10175 2195274..2195525 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
FPJ54_RS10180 2195512..2196006 + 495 WP_003899099.1 hypothetical protein -
FPJ54_RS10185 2196166..2196573 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ54_RS10190 2196577..2196849 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ54_RS10195 2196882..2198102 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-113)

Antitoxin

(44-91)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T133269 WP_010886136.1 NZ_CP041854:2193019-2193396 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T133269 NZ_CP041854:2193019-2193396 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT133269 WP_003409886.1 NZ_CP041854:2193438-2193887 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT133269 NZ_CP041854:2193438-2193887 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCATCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU


Antitoxin

Source ID Structure
PDB 5MTW
AlphaFold DB G0TLM0

References