132807

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2971173..2971821 Replicon chromosome
Accession NZ_CP041846
Organism Mycobacterium tuberculosis strain 1-0153P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ62_RS13855 Protein ID WP_003899414.1
Coordinates 2971173..2971496 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ62_RS13860 Protein ID WP_003899415.1
Coordinates 2971576..2971821 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ62_RS13825 2966496..2967494 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ62_RS13830 2967508..2967972 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ62_RS13835 2967960..2968211 + 252 WP_003908028.1 hypothetical protein -
FPJ62_RS13840 2968382..2969821 - 1440 WP_003901443.1 phage major capsid protein -
FPJ62_RS13845 2969829..2970362 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ62_RS13850 2970515..2971006 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ62_RS13855 2971173..2971496 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ62_RS13860 2971576..2971821 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ62_RS13865 2971818..2973245 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ62_RS13870 2973247..2973639 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ62_RS13875 2973636..2973896 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ62_RS13880 2973913..2974275 - 363 WP_003900543.1 hypothetical protein -
FPJ62_RS13885 2974278..2975405 - 1128 WP_003899420.1 site-specific integrase -
FPJ62_RS13890 2975550..2975777 - 228 WP_003899421.1 hypothetical protein -
FPJ62_RS13895 2975774..2976163 - 390 WP_003899422.1 hypothetical protein -
FPJ62_RS13900 2976069..2976341 + 273 WP_003900544.1 hypothetical protein -
FPJ62_RS13905 2976440..2976673 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2966496..2975405 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T132807 WP_003899414.1 NZ_CP041846:c2971496-2971173 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T132807 NZ_CP041846:c2971496-2971173 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT132807 WP_003899415.1 NZ_CP041846:c2971821-2971576 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT132807 NZ_CP041846:c2971821-2971576 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References