Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2985164..2985812 Replicon chromosome
Accession NZ_CP041845
Organism Mycobacterium tuberculosis strain 1-0156P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ63_RS13945 Protein ID WP_003899414.1
Coordinates 2985164..2985487 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ63_RS13950 Protein ID WP_003899415.1
Coordinates 2985567..2985812 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ63_RS13915 2980487..2981485 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ63_RS13920 2981499..2981963 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ63_RS13925 2981951..2982202 + 252 WP_003908028.1 hypothetical protein -
FPJ63_RS13930 2982373..2983812 - 1440 WP_003899411.1 phage major capsid protein -
FPJ63_RS13935 2983820..2984353 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ63_RS13940 2984506..2984997 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ63_RS13945 2985164..2985487 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ63_RS13950 2985567..2985812 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ63_RS13955 2985809..2987236 - 1428 WP_031654718.1 DUF3631 domain-containing protein -
FPJ63_RS13960 2987238..2987630 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ63_RS13965 2987627..2987887 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ63_RS13970 2987904..2988266 - 363 WP_003900543.1 hypothetical protein -
FPJ63_RS13975 2988269..2989396 - 1128 WP_003899420.1 site-specific integrase -
FPJ63_RS13980 2989541..2989768 - 228 WP_003899421.1 hypothetical protein -
FPJ63_RS13985 2989765..2990154 - 390 WP_003899422.1 hypothetical protein -
FPJ63_RS13990 2990060..2990332 + 273 WP_003900544.1 hypothetical protein -
FPJ63_RS13995 2990431..2990664 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2980487..2989396 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T132747 WP_003899414.1 NZ_CP041845:c2985487-2985164 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T132747 NZ_CP041845:c2985487-2985164 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT132747 WP_003899415.1 NZ_CP041845:c2985812-2985567 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT132747 NZ_CP041845:c2985812-2985567 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References