Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2992062..2992710 Replicon chromosome
Accession NZ_CP041844
Organism Mycobacterium tuberculosis strain 1-0160P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ64_RS13980 Protein ID WP_003899414.1
Coordinates 2992062..2992385 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ64_RS13985 Protein ID WP_003899415.1
Coordinates 2992465..2992710 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ64_RS13950 2987386..2988384 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ64_RS13955 2988398..2988862 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ64_RS13960 2988850..2989101 + 252 WP_003908028.1 hypothetical protein -
FPJ64_RS13965 2989272..2990711 - 1440 WP_003901443.1 phage major capsid protein -
FPJ64_RS13970 2990719..2991252 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ64_RS13975 2991405..2991896 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ64_RS13980 2992062..2992385 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ64_RS13985 2992465..2992710 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ64_RS13990 2992707..2994133 - 1427 Protein_2759 DUF3631 domain-containing protein -
FPJ64_RS13995 2994135..2994527 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ64_RS14000 2994524..2994784 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ64_RS14005 2994801..2995163 - 363 WP_003900543.1 hypothetical protein -
FPJ64_RS14010 2995166..2996293 - 1128 WP_003899420.1 site-specific integrase -
FPJ64_RS14015 2996438..2996665 - 228 WP_003899421.1 hypothetical protein -
FPJ64_RS14020 2996662..2997051 - 390 WP_003899422.1 hypothetical protein -
FPJ64_RS14025 2996957..2997229 + 273 WP_003900544.1 hypothetical protein -
FPJ64_RS14030 2997328..2997561 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2987386..2996293 8907


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-68)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T132686 WP_003899414.1 NZ_CP041844:c2992385-2992062 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T132686 NZ_CP041844:c2992385-2992062 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT132686 WP_003899415.1 NZ_CP041844:c2992710-2992465 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT132686 NZ_CP041844:c2992710-2992465 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References