Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2973795..2974443 Replicon chromosome
Accession NZ_CP041843
Organism Mycobacterium tuberculosis strain 1-0168P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ65_RS13885 Protein ID WP_003899414.1
Coordinates 2973795..2974118 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ65_RS13890 Protein ID WP_003899415.1
Coordinates 2974198..2974443 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ65_RS13855 2969118..2970116 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ65_RS13860 2970130..2970594 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ65_RS13865 2970582..2970833 + 252 WP_003908028.1 hypothetical protein -
FPJ65_RS13870 2971004..2972443 - 1440 WP_003899411.1 phage major capsid protein -
FPJ65_RS13875 2972451..2972984 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ65_RS13880 2973137..2973628 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ65_RS13885 2973795..2974118 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ65_RS13890 2974198..2974443 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ65_RS13895 2974440..2975867 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ65_RS13900 2975869..2976261 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ65_RS13905 2976258..2976518 - 261 WP_014585547.1 helix-turn-helix domain-containing protein -
FPJ65_RS13910 2976535..2976897 - 363 WP_003900543.1 hypothetical protein -
FPJ65_RS13915 2976900..2978027 - 1128 WP_003899420.1 site-specific integrase -
FPJ65_RS13920 2978172..2978399 - 228 WP_003899421.1 hypothetical protein -
FPJ65_RS13925 2978396..2978785 - 390 WP_003899422.1 hypothetical protein -
FPJ65_RS13930 2978691..2978963 + 273 WP_003900544.1 hypothetical protein -
FPJ65_RS13935 2979062..2979295 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2969118..2978027 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T132626 WP_003899414.1 NZ_CP041843:c2974118-2973795 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T132626 NZ_CP041843:c2974118-2973795 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT132626 WP_003899415.1 NZ_CP041843:c2974443-2974198 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT132626 NZ_CP041843:c2974443-2974198 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References