132489

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2207959..2208827 Replicon chromosome
Accession NZ_CP041841
Organism Mycobacterium tuberculosis strain 2-0021P6C4

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag FPJ67_RS10175 Protein ID WP_010886136.1
Coordinates 2207959..2208336 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag FPJ67_RS10180 Protein ID WP_003409886.1
Coordinates 2208378..2208827 (+) Length 150 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ67_RS10125 2203748..2204200 - 453 WP_003899095.1 lipoprotein -
FPJ67_RS10130 2204264..2204665 + 402 WP_003409869.1 hypothetical protein -
FPJ67_RS10135 2204658..2204840 - 183 WP_003409870.1 hypothetical protein -
FPJ67_RS10140 2204954..2205304 - 351 WP_003899096.1 hypothetical protein -
FPJ67_RS10145 2205315..2206217 - 903 WP_003899097.1 hypothetical protein -
FPJ67_RS10150 2206238..2206429 - 192 WP_003409876.1 hypothetical protein -
FPJ67_RS10155 2206430..2206726 - 297 WP_003409877.1 hypothetical protein -
FPJ67_RS10160 2206966..2207181 + 216 WP_003409878.1 antitoxin -
FPJ67_RS10165 2207178..2207489 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ67_RS10170 2207463..2207984 - 522 WP_003904745.1 hypothetical protein -
FPJ67_RS10175 2207959..2208336 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
FPJ67_RS10180 2208378..2208827 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
FPJ67_RS10185 2208824..2209369 + 546 WP_003409891.1 SecB-like chaperone -
FPJ67_RS10190 2209258..2209872 - 615 WP_003901296.1 hypothetical protein -
FPJ67_RS10195 2209921..2210217 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPJ67_RS10200 2210214..2210465 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
FPJ67_RS10205 2210452..2210946 + 495 WP_003899099.1 hypothetical protein -
FPJ67_RS10210 2211106..2211513 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ67_RS10215 2211517..2211789 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ67_RS10220 2211822..2213042 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-113)

Antitoxin

(44-91)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T132489 WP_010886136.1 NZ_CP041841:2207959-2208336 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T132489 NZ_CP041841:2207959-2208336 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT132489 WP_003409886.1 NZ_CP041841:2208378-2208827 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT132489 NZ_CP041841:2208378-2208827 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU


Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References