Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2988712..2989360 Replicon chromosome
Accession NZ_CP041839
Organism Mycobacterium tuberculosis strain 2-0023P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ69_RS13915 Protein ID WP_003899414.1
Coordinates 2988712..2989035 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ69_RS13920 Protein ID WP_003899415.1
Coordinates 2989115..2989360 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ69_RS13885 2984035..2985033 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ69_RS13890 2985047..2985511 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ69_RS13895 2985499..2985750 + 252 WP_003908028.1 hypothetical protein -
FPJ69_RS13900 2985921..2987360 - 1440 WP_003899411.1 phage major capsid protein -
FPJ69_RS13905 2987368..2987901 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ69_RS13910 2988054..2988545 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ69_RS13915 2988712..2989035 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ69_RS13920 2989115..2989360 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ69_RS13925 2989357..2990784 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ69_RS13930 2990786..2991178 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ69_RS13935 2991175..2991435 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ69_RS13940 2991452..2991814 - 363 WP_003900543.1 hypothetical protein -
FPJ69_RS13945 2991817..2992944 - 1128 WP_003899420.1 site-specific integrase -
FPJ69_RS13950 2993089..2993316 - 228 WP_003899421.1 hypothetical protein -
FPJ69_RS13955 2993313..2993702 - 390 WP_003899422.1 hypothetical protein -
FPJ69_RS13960 2993608..2993880 + 273 WP_003900544.1 hypothetical protein -
FPJ69_RS13965 2993979..2994212 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2984035..2992944 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(37-142)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T132383 WP_003899414.1 NZ_CP041839:c2989035-2988712 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T132383 NZ_CP041839:c2989035-2988712 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT132383 WP_003899415.1 NZ_CP041839:c2989360-2989115 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT132383 NZ_CP041839:c2989360-2989115 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References