132190

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2749674..2750322 Replicon chromosome
Accession NZ_CP041836
Organism Mycobacterium tuberculosis strain 2-0031P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ72_RS12720 Protein ID WP_003899414.1
Coordinates 2749674..2749997 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ72_RS12725 Protein ID WP_003899415.1
Coordinates 2750077..2750322 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ72_RS12690 2744997..2745995 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ72_RS12695 2746009..2746473 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ72_RS12700 2746461..2746712 + 252 WP_003908028.1 hypothetical protein -
FPJ72_RS12705 2746883..2748322 - 1440 WP_003901443.1 phage major capsid protein -
FPJ72_RS12710 2748330..2748863 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ72_RS12715 2749016..2749507 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ72_RS12720 2749674..2749997 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ72_RS12725 2750077..2750322 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ72_RS12730 2750319..2751746 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ72_RS12735 2751748..2752140 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ72_RS12740 2752137..2752397 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ72_RS12745 2752414..2752776 - 363 WP_003900543.1 hypothetical protein -
FPJ72_RS12750 2752779..2753906 - 1128 WP_003899420.1 site-specific integrase -
FPJ72_RS12755 2754051..2754278 - 228 WP_003899421.1 hypothetical protein -
FPJ72_RS12760 2754275..2754664 - 390 WP_003899422.1 hypothetical protein -
FPJ72_RS12765 2754570..2754842 + 273 WP_003900544.1 hypothetical protein -
FPJ72_RS12770 2754941..2755174 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2744997..2756993 11996


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T132190 WP_003899414.1 NZ_CP041836:c2749997-2749674 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T132190 NZ_CP041836:c2749997-2749674 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT132190 WP_003899415.1 NZ_CP041836:c2750322-2750077 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT132190 NZ_CP041836:c2750322-2750077 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References