132164

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 863468..864138 Replicon chromosome
Accession NZ_CP041836
Organism Mycobacterium tuberculosis strain 2-0031P6C4

Toxin (Protein)


Gene name higB Uniprot ID O53332
Locus tag FPJ72_RS03945 Protein ID WP_003899954.1
Coordinates 863794..864138 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0THF6
Locus tag FPJ72_RS03940 Protein ID WP_003899955.1
Coordinates 863468..863797 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ72_RS03910 858883..859917 + 1035 WP_003416786.1 IS30 family transposase -
FPJ72_RS03915 859944..860129 - 186 WP_031655312.1 hypothetical protein -
FPJ72_RS03920 860164..860373 - 210 WP_003416778.1 hypothetical protein -
FPJ72_RS03925 860541..861806 + 1266 WP_003902423.1 hypothetical protein -
FPJ72_RS03930 861966..862586 - 621 WP_003899957.1 RES family NAD+ phosphorylase -
FPJ72_RS03935 862583..862930 - 348 WP_003899956.1 DUF2384 domain-containing protein -
FPJ72_RS03940 863468..863797 - 330 WP_003899955.1 XRE family transcriptional regulator Antitoxin
FPJ72_RS03945 863794..864138 - 345 WP_003899954.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPJ72_RS03950 864369..864821 + 453 WP_003899953.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ72_RS03955 864824..865258 + 435 WP_003899952.1 type II toxin-antitoxin system VapC family toxin -
FPJ72_RS03960 865367..866628 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
FPJ72_RS03965 866963..868252 - 1290 WP_003416640.1 ATP-binding protein -
FPJ72_RS03970 868540..868833 - 294 WP_003416635.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12692.50 Da        Isoelectric Point: 5.6920

>T132164 WP_003899954.1 NZ_CP041836:c864138-863794 [Mycobacterium tuberculosis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG

Download         Length: 345 bp

>T132164 NZ_CP041836:c864138-863794 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11802.46 Da        Isoelectric Point: 7.4051

>AT132164 WP_003899955.1 NZ_CP041836:c863797-863468 [Mycobacterium tuberculosis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA

Download         Length: 330 bp

>AT132164 NZ_CP041836:c863797-863468 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCGGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBK2

Antitoxin

Source ID Structure
AlphaFold DB G0THF6

References