132140

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2965806..2966454 Replicon chromosome
Accession NZ_CP041835
Organism Mycobacterium tuberculosis strain 2-0034P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ73_RS13870 Protein ID WP_003899414.1
Coordinates 2965806..2966129 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ73_RS13875 Protein ID WP_003899415.1
Coordinates 2966209..2966454 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ73_RS13840 2961128..2962126 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ73_RS13845 2962140..2962604 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ73_RS13850 2962592..2962843 + 252 WP_003908028.1 hypothetical protein -
FPJ73_RS13855 2963014..2964453 - 1440 WP_003901443.1 phage major capsid protein -
FPJ73_RS13860 2964461..2964994 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ73_RS13865 2965147..2965638 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ73_RS13870 2965806..2966129 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ73_RS13875 2966209..2966454 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ73_RS13880 2966451..2967878 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ73_RS13885 2967880..2968272 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ73_RS13890 2968269..2968529 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ73_RS13895 2968546..2968908 - 363 WP_003900543.1 hypothetical protein -
FPJ73_RS13900 2968911..2970038 - 1128 WP_003899420.1 site-specific integrase -
FPJ73_RS13905 2970183..2970410 - 228 WP_003899421.1 hypothetical protein -
FPJ73_RS13910 2970407..2970796 - 390 WP_003899422.1 hypothetical protein -
FPJ73_RS13915 2970702..2970974 + 273 WP_003900544.1 hypothetical protein -
FPJ73_RS13920 2971073..2971306 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2961128..2970038 8910


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T132140 WP_003899414.1 NZ_CP041835:c2966129-2965806 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T132140 NZ_CP041835:c2966129-2965806 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT132140 WP_003899415.1 NZ_CP041835:c2966454-2966209 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT132140 NZ_CP041835:c2966454-2966209 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References