Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2188032..2188900 Replicon chromosome
Accession NZ_CP041835
Organism Mycobacterium tuberculosis strain 2-0034P6C4

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag FPJ73_RS10110 Protein ID WP_010886136.1
Coordinates 2188032..2188409 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag FPJ73_RS10115 Protein ID WP_003409886.1
Coordinates 2188451..2188900 (+) Length 150 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ73_RS10060 2183821..2184273 - 453 WP_003899095.1 lipoprotein -
FPJ73_RS10065 2184337..2184738 + 402 WP_003409869.1 hypothetical protein -
FPJ73_RS10070 2184731..2184913 - 183 WP_003409870.1 hypothetical protein -
FPJ73_RS10075 2185027..2185377 - 351 WP_003409871.1 hypothetical protein -
FPJ73_RS10080 2185388..2186290 - 903 WP_003899097.1 hypothetical protein -
FPJ73_RS10085 2186311..2186502 - 192 WP_003409876.1 hypothetical protein -
FPJ73_RS10090 2186503..2186799 - 297 WP_003409877.1 hypothetical protein -
FPJ73_RS10095 2187039..2187254 + 216 WP_003409878.1 antitoxin -
FPJ73_RS10100 2187251..2187562 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ73_RS10105 2187536..2188057 - 522 WP_003904745.1 hypothetical protein -
FPJ73_RS10110 2188032..2188409 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
FPJ73_RS10115 2188451..2188900 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
FPJ73_RS10120 2188897..2189442 + 546 WP_003409891.1 SecB-like chaperone -
FPJ73_RS10125 2189331..2189945 - 615 WP_003901296.1 hypothetical protein -
FPJ73_RS10130 2189994..2190290 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPJ73_RS10135 2190287..2190538 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
FPJ73_RS10140 2190525..2191019 + 495 WP_003899099.1 hypothetical protein -
FPJ73_RS10145 2191179..2191586 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ73_RS10150 2191590..2191862 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ73_RS10155 2191895..2193115 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-113)

Antitoxin

(44-91)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T132124 WP_010886136.1 NZ_CP041835:2188032-2188409 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T132124 NZ_CP041835:2188032-2188409 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT132124 WP_003409886.1 NZ_CP041835:2188451-2188900 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT132124 NZ_CP041835:2188451-2188900 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCATCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU


Antitoxin

Source ID Structure
PDB 5MTW
AlphaFold DB G0TLM0

References