Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2203052..2203920 Replicon chromosome
Accession NZ_CP041834
Organism Mycobacterium tuberculosis strain 2-0043-unknownP6C4

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag FPJ74_RS10155 Protein ID WP_010886136.1
Coordinates 2203052..2203429 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag FPJ74_RS10160 Protein ID WP_003409886.1
Coordinates 2203471..2203920 (+) Length 150 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ74_RS10105 2198841..2199293 - 453 WP_003899095.1 lipoprotein -
FPJ74_RS10110 2199357..2199758 + 402 WP_003409869.1 hypothetical protein -
FPJ74_RS10115 2199751..2199933 - 183 WP_003409870.1 hypothetical protein -
FPJ74_RS10120 2200047..2200397 - 351 WP_003899096.1 hypothetical protein -
FPJ74_RS10125 2200408..2201310 - 903 WP_003899097.1 hypothetical protein -
FPJ74_RS10130 2201331..2201522 - 192 WP_003409876.1 hypothetical protein -
FPJ74_RS10135 2201523..2201819 - 297 WP_003409877.1 hypothetical protein -
FPJ74_RS10140 2202059..2202274 + 216 WP_003409878.1 antitoxin -
FPJ74_RS10145 2202271..2202582 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ74_RS10150 2202556..2203077 - 522 WP_003904745.1 hypothetical protein -
FPJ74_RS10155 2203052..2203429 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
FPJ74_RS10160 2203471..2203920 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
FPJ74_RS10165 2203917..2204462 + 546 WP_003899098.1 SecB-like chaperone -
FPJ74_RS10170 2204351..2204965 - 615 WP_003901296.1 hypothetical protein -
FPJ74_RS10175 2205014..2205310 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPJ74_RS10180 2205307..2205558 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
FPJ74_RS10185 2205545..2206039 + 495 WP_003899099.1 hypothetical protein -
FPJ74_RS10190 2206199..2206606 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ74_RS10195 2206610..2206882 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ74_RS10200 2206915..2208135 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-113)

Antitoxin

(44-91)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T132064 WP_010886136.1 NZ_CP041834:2203052-2203429 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T132064 NZ_CP041834:2203052-2203429 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT132064 WP_003409886.1 NZ_CP041834:2203471-2203920 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT132064 NZ_CP041834:2203471-2203920 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU


Antitoxin

Source ID Structure
PDB 5MTW
AlphaFold DB G0TLM0

References