Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2965683..2966331 Replicon chromosome
Accession NZ_CP041832
Organism Mycobacterium tuberculosis strain 2-0052P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ76_RS13860 Protein ID WP_003899414.1
Coordinates 2965683..2966006 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ76_RS13865 Protein ID WP_003899415.1
Coordinates 2966086..2966331 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ76_RS13830 2961006..2962004 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ76_RS13835 2962018..2962482 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ76_RS13840 2962470..2962721 + 252 WP_003908028.1 hypothetical protein -
FPJ76_RS13845 2962892..2964331 - 1440 WP_003901443.1 phage major capsid protein -
FPJ76_RS13850 2964339..2964872 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ76_RS13855 2965025..2965516 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ76_RS13860 2965683..2966006 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ76_RS13865 2966086..2966331 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ76_RS13870 2966328..2967755 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ76_RS13875 2967757..2968149 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ76_RS13880 2968146..2968406 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ76_RS13885 2968423..2968785 - 363 WP_003900543.1 hypothetical protein -
FPJ76_RS13890 2968788..2969915 - 1128 WP_003899420.1 site-specific integrase -
FPJ76_RS13895 2970060..2970287 - 228 WP_003899421.1 hypothetical protein -
FPJ76_RS13900 2970284..2970673 - 390 WP_003899422.1 hypothetical protein -
FPJ76_RS13905 2970579..2970851 + 273 WP_003900544.1 hypothetical protein -
FPJ76_RS13910 2970950..2971183 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2961006..2969915 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T131958 WP_003899414.1 NZ_CP041832:c2966006-2965683 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T131958 NZ_CP041832:c2966006-2965683 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131958 WP_003899415.1 NZ_CP041832:c2966331-2966086 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131958 NZ_CP041832:c2966331-2966086 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References