131898

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2987483..2988131 Replicon chromosome
Accession NZ_CP041831
Organism Mycobacterium tuberculosis strain 2-0059P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ77_RS13905 Protein ID WP_003899414.1
Coordinates 2987483..2987806 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ77_RS13910 Protein ID WP_003899415.1
Coordinates 2987886..2988131 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ77_RS13875 2982806..2983804 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ77_RS13880 2983818..2984282 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ77_RS13885 2984270..2984521 + 252 WP_003908028.1 hypothetical protein -
FPJ77_RS13890 2984692..2986131 - 1440 WP_031714268.1 phage major capsid protein -
FPJ77_RS13895 2986139..2986672 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ77_RS13900 2986825..2987316 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ77_RS13905 2987483..2987806 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ77_RS13910 2987886..2988131 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ77_RS13915 2988128..2989554 - 1427 Protein_2744 DUF3631 domain-containing protein -
FPJ77_RS13920 2989556..2989948 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ77_RS13925 2989945..2990205 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ77_RS13930 2990222..2990584 - 363 WP_003900543.1 hypothetical protein -
FPJ77_RS13935 2990587..2991714 - 1128 WP_003899420.1 site-specific integrase -
FPJ77_RS13940 2991859..2992086 - 228 WP_003899421.1 hypothetical protein -
FPJ77_RS13945 2992083..2992472 - 390 WP_003899422.1 hypothetical protein -
FPJ77_RS13950 2992378..2992650 + 273 WP_003900544.1 hypothetical protein -
FPJ77_RS13955 2992749..2992982 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2982806..2991714 8908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(8-88)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T131898 WP_003899414.1 NZ_CP041831:c2987806-2987483 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T131898 NZ_CP041831:c2987806-2987483 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131898 WP_003899415.1 NZ_CP041831:c2988131-2987886 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131898 NZ_CP041831:c2988131-2987886 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References