Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2973637..2974285 Replicon chromosome
Accession NZ_CP041830
Organism Mycobacterium tuberculosis strain 2-0068P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ78_RS13900 Protein ID WP_003899414.1
Coordinates 2973637..2973960 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ78_RS13905 Protein ID WP_003899415.1
Coordinates 2974040..2974285 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ78_RS13870 2968960..2969958 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ78_RS13875 2969972..2970436 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ78_RS13880 2970424..2970675 + 252 WP_003908028.1 hypothetical protein -
FPJ78_RS13885 2970846..2972285 - 1440 WP_003901443.1 phage major capsid protein -
FPJ78_RS13890 2972293..2972826 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ78_RS13895 2972979..2973470 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ78_RS13900 2973637..2973960 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ78_RS13905 2974040..2974285 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ78_RS13910 2974282..2975709 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ78_RS13915 2975711..2976103 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ78_RS13920 2976100..2976360 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ78_RS13925 2976377..2976739 - 363 WP_003900543.1 hypothetical protein -
FPJ78_RS13930 2976742..2977869 - 1128 WP_003899420.1 site-specific integrase -
FPJ78_RS13935 2978014..2978241 - 228 WP_003899421.1 hypothetical protein -
FPJ78_RS13940 2978238..2978627 - 390 WP_003899422.1 hypothetical protein -
FPJ78_RS13945 2978533..2978805 + 273 WP_003900544.1 hypothetical protein -
FPJ78_RS13950 2978904..2979137 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2968960..2977869 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T131837 WP_003899414.1 NZ_CP041830:c2973960-2973637 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T131837 NZ_CP041830:c2973960-2973637 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131837 WP_003899415.1 NZ_CP041830:c2974285-2974040 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131837 NZ_CP041830:c2974285-2974040 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References