Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2990496..2991144 Replicon chromosome
Accession NZ_CP041828
Organism Mycobacterium tuberculosis strain 3-0090P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPJ80_RS13925 Protein ID WP_003903987.1
Coordinates 2990496..2990819 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ80_RS13930 Protein ID WP_003899415.1
Coordinates 2990899..2991144 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ80_RS13895 2985819..2986817 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
FPJ80_RS13900 2986831..2987295 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ80_RS13905 2987283..2987534 + 252 WP_003908028.1 hypothetical protein -
FPJ80_RS13910 2987705..2989144 - 1440 WP_003901443.1 phage major capsid protein -
FPJ80_RS13915 2989152..2989685 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ80_RS13920 2989838..2990329 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ80_RS13925 2990496..2990819 - 324 WP_003903987.1 type II toxin-antitoxin system toxin Toxin
FPJ80_RS13930 2990899..2991144 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ80_RS13935 2991141..2992568 - 1428 WP_003908030.1 DUF3631 domain-containing protein -
FPJ80_RS13940 2992570..2992962 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ80_RS13945 2992959..2993219 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ80_RS13950 2993236..2993598 - 363 WP_003900543.1 hypothetical protein -
FPJ80_RS13955 2993601..2994728 - 1128 WP_003899420.1 site-specific integrase -
FPJ80_RS13960 2994873..2995100 - 228 WP_003899421.1 hypothetical protein -
FPJ80_RS13965 2995097..2995486 - 390 WP_003899422.1 hypothetical protein -
FPJ80_RS13970 2995392..2995664 + 273 WP_003900544.1 hypothetical protein -
FPJ80_RS13975 2995763..2995996 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2985819..2994728 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12353.82 Da        Isoelectric Point: 7.4705

>T131717 WP_003903987.1 NZ_CP041828:c2990819-2990496 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T131717 NZ_CP041828:c2990819-2990496 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131717 WP_003899415.1 NZ_CP041828:c2991144-2990899 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131717 NZ_CP041828:c2991144-2990899 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References