Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 3001813..3002461 Replicon chromosome
Accession NZ_CP041827
Organism Mycobacterium tuberculosis strain 3-0096P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPJ81_RS13990 Protein ID WP_003903987.1
Coordinates 3001813..3002136 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ81_RS13995 Protein ID WP_003899415.1
Coordinates 3002216..3002461 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ81_RS13960 2997136..2998134 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
FPJ81_RS13965 2998148..2998612 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ81_RS13970 2998600..2998851 + 252 WP_003908028.1 hypothetical protein -
FPJ81_RS13975 2999022..3000461 - 1440 WP_003901443.1 phage major capsid protein -
FPJ81_RS13980 3000469..3001002 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ81_RS13985 3001155..3001646 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ81_RS13990 3001813..3002136 - 324 WP_003903987.1 type II toxin-antitoxin system toxin Toxin
FPJ81_RS13995 3002216..3002461 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ81_RS14000 3002458..3003885 - 1428 WP_003908030.1 DUF3631 domain-containing protein -
FPJ81_RS14005 3003887..3004279 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ81_RS14010 3004276..3004536 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ81_RS14015 3004553..3004915 - 363 WP_003900543.1 hypothetical protein -
FPJ81_RS14020 3004918..3006045 - 1128 WP_003899420.1 site-specific integrase -
FPJ81_RS14025 3006190..3006417 - 228 WP_003899421.1 hypothetical protein -
FPJ81_RS14030 3006414..3006803 - 390 WP_003899422.1 hypothetical protein -
FPJ81_RS14035 3006709..3006981 + 273 WP_003900544.1 hypothetical protein -
FPJ81_RS14040 3007080..3007313 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2997136..3006045 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12353.82 Da        Isoelectric Point: 7.4705

>T131656 WP_003903987.1 NZ_CP041827:c3002136-3001813 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T131656 NZ_CP041827:c3002136-3001813 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131656 WP_003899415.1 NZ_CP041827:c3002461-3002216 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131656 NZ_CP041827:c3002461-3002216 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References