Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 1437837..1438485 Replicon chromosome
Accession NZ_CP041823
Organism Mycobacterium tuberculosis strain 4-0019P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ85_RS06820 Protein ID WP_003899414.1
Coordinates 1438162..1438485 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ85_RS06815 Protein ID WP_003899415.1
Coordinates 1437837..1438082 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ85_RS06770 1432985..1433218 - 234 WP_003413717.1 hypothetical protein -
FPJ85_RS06775 1433317..1433589 - 273 WP_003900544.1 hypothetical protein -
FPJ85_RS06780 1433495..1433884 + 390 WP_003899422.1 hypothetical protein -
FPJ85_RS06785 1433881..1434108 + 228 WP_003899421.1 hypothetical protein -
FPJ85_RS06790 1434253..1435380 + 1128 WP_003899420.1 site-specific integrase -
FPJ85_RS06795 1435383..1435745 + 363 WP_003900543.1 hypothetical protein -
FPJ85_RS06800 1435762..1436022 + 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ85_RS06805 1436019..1436411 + 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ85_RS06810 1436413..1437840 + 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ85_RS06815 1437837..1438082 + 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ85_RS06820 1438162..1438485 + 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ85_RS06825 1438652..1439143 + 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ85_RS06830 1439296..1439829 + 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ85_RS06835 1439837..1441276 + 1440 WP_003899411.1 phage major capsid protein -
FPJ85_RS06840 1441447..1441698 - 252 WP_003908028.1 hypothetical protein -
FPJ85_RS06845 1441686..1442150 - 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ85_RS06850 1442164..1443162 - 999 WP_003900538.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1434253..1443162 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(15-89)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T131392 WP_003899414.1 NZ_CP041823:1438162-1438485 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T131392 NZ_CP041823:1438162-1438485 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131392 WP_003899415.1 NZ_CP041823:1437837-1438082 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131392 NZ_CP041823:1437837-1438082 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References