131331

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 1437781..1438429 Replicon chromosome
Accession NZ_CP041822
Organism Mycobacterium tuberculosis strain 4-0024P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ86_RS06825 Protein ID WP_003899414.1
Coordinates 1438106..1438429 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ86_RS06820 Protein ID WP_003899415.1
Coordinates 1437781..1438026 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ86_RS06775 1432929..1433162 - 234 WP_003413717.1 hypothetical protein -
FPJ86_RS06780 1433261..1433533 - 273 WP_003900544.1 hypothetical protein -
FPJ86_RS06785 1433439..1433828 + 390 WP_003899422.1 hypothetical protein -
FPJ86_RS06790 1433825..1434052 + 228 WP_003899421.1 hypothetical protein -
FPJ86_RS06795 1434197..1435324 + 1128 WP_003899420.1 site-specific integrase -
FPJ86_RS06800 1435327..1435689 + 363 WP_003900543.1 hypothetical protein -
FPJ86_RS06805 1435706..1435966 + 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ86_RS06810 1435963..1436355 + 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ86_RS06815 1436357..1437784 + 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ86_RS06820 1437781..1438026 + 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ86_RS06825 1438106..1438429 + 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ86_RS06830 1438596..1439087 + 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ86_RS06835 1439240..1439773 + 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ86_RS06840 1439781..1441220 + 1440 WP_003899411.1 phage major capsid protein -
FPJ86_RS06845 1441391..1441642 - 252 WP_003908028.1 hypothetical protein -
FPJ86_RS06850 1441630..1442094 - 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ86_RS06855 1442108..1443106 - 999 WP_003900538.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1434197..1443106 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T131331 WP_003899414.1 NZ_CP041822:1438106-1438429 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T131331 NZ_CP041822:1438106-1438429 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131331 WP_003899415.1 NZ_CP041822:1437781-1438026 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131331 NZ_CP041822:1437781-1438026 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References