131293

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2963006..2963654 Replicon chromosome
Accession NZ_CP041821
Organism Mycobacterium tuberculosis strain 4-0062P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ88_RS13840 Protein ID WP_003899414.1
Coordinates 2963006..2963329 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ88_RS13845 Protein ID WP_003899415.1
Coordinates 2963409..2963654 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ88_RS13810 2958329..2959327 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ88_RS13815 2959341..2959805 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ88_RS13820 2959793..2960044 + 252 WP_003908028.1 hypothetical protein -
FPJ88_RS13825 2960215..2961654 - 1440 WP_003901443.1 phage major capsid protein -
FPJ88_RS13830 2961662..2962195 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ88_RS13835 2962348..2962839 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ88_RS13840 2963006..2963329 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ88_RS13845 2963409..2963654 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ88_RS13850 2963651..2965078 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ88_RS13855 2965080..2965472 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ88_RS13860 2965469..2965729 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ88_RS13865 2965746..2966108 - 363 WP_003900543.1 hypothetical protein -
FPJ88_RS13870 2966111..2967238 - 1128 WP_003899420.1 site-specific integrase -
FPJ88_RS13875 2967383..2967610 - 228 WP_003899421.1 hypothetical protein -
FPJ88_RS13880 2967607..2967996 - 390 WP_003899422.1 hypothetical protein -
FPJ88_RS13885 2967902..2968176 + 275 Protein_2738 hypothetical protein -
FPJ88_RS13890 2968275..2968508 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2958329..2967238 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T131293 WP_003899414.1 NZ_CP041821:c2963329-2963006 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T131293 NZ_CP041821:c2963329-2963006 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131293 WP_003899415.1 NZ_CP041821:c2963654-2963409 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131293 NZ_CP041821:c2963654-2963409 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References