131232

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2985628..2986276 Replicon chromosome
Accession NZ_CP041820
Organism Mycobacterium tuberculosis strain 4-0073P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ89_RS13920 Protein ID WP_003899414.1
Coordinates 2985628..2985951 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ89_RS13925 Protein ID WP_003899415.1
Coordinates 2986031..2986276 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ89_RS13890 2980952..2981950 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ89_RS13895 2981964..2982428 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ89_RS13900 2982416..2982667 + 252 WP_003908028.1 hypothetical protein -
FPJ89_RS13905 2982838..2984277 - 1440 WP_003899411.1 phage major capsid protein -
FPJ89_RS13910 2984285..2984818 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ89_RS13915 2984971..2985462 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ89_RS13920 2985628..2985951 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ89_RS13925 2986031..2986276 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ89_RS13930 2986273..2987700 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ89_RS13935 2987702..2988094 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ89_RS13940 2988091..2988351 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ89_RS13945 2988368..2988730 - 363 WP_003900543.1 hypothetical protein -
FPJ89_RS13950 2988733..2989860 - 1128 WP_003899420.1 site-specific integrase -
FPJ89_RS13955 2990005..2990232 - 228 WP_003899421.1 hypothetical protein -
FPJ89_RS13960 2990229..2990618 - 390 WP_003899422.1 hypothetical protein -
FPJ89_RS13965 2990524..2990796 + 273 WP_003900544.1 hypothetical protein -
FPJ89_RS13970 2990895..2991128 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2980952..2989860 8908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T131232 WP_003899414.1 NZ_CP041820:c2985951-2985628 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T131232 NZ_CP041820:c2985951-2985628 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131232 WP_003899415.1 NZ_CP041820:c2986276-2986031 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131232 NZ_CP041820:c2986276-2986031 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References