Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2964616..2965264 Replicon chromosome
Accession NZ_CP041819
Organism Mycobacterium tuberculosis strain 4-0077P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ90_RS13865 Protein ID WP_003899414.1
Coordinates 2964616..2964939 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ90_RS13870 Protein ID WP_003899415.1
Coordinates 2965019..2965264 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ90_RS13835 2959939..2960937 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ90_RS13840 2960951..2961415 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ90_RS13845 2961403..2961654 + 252 WP_003908028.1 hypothetical protein -
FPJ90_RS13850 2961825..2963264 - 1440 WP_003901443.1 phage major capsid protein -
FPJ90_RS13855 2963272..2963805 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ90_RS13860 2963958..2964449 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ90_RS13865 2964616..2964939 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ90_RS13870 2965019..2965264 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ90_RS13875 2965261..2966688 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ90_RS13880 2966690..2967082 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ90_RS13885 2967079..2967339 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ90_RS13890 2967356..2967718 - 363 WP_003900543.1 hypothetical protein -
FPJ90_RS13895 2967721..2968848 - 1128 WP_003899420.1 site-specific integrase -
FPJ90_RS13900 2968993..2969220 - 228 WP_003899421.1 hypothetical protein -
FPJ90_RS13905 2969217..2969606 - 390 WP_003899422.1 hypothetical protein -
FPJ90_RS13910 2969512..2969786 + 275 Protein_2743 hypothetical protein -
FPJ90_RS13915 2969885..2970118 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2959939..2968848 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-147)

Antitoxin

PrlF antitoxin

(15-109)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T131171 WP_003899414.1 NZ_CP041819:c2964939-2964616 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T131171 NZ_CP041819:c2964939-2964616 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131171 WP_003899415.1 NZ_CP041819:c2965264-2965019 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131171 NZ_CP041819:c2965264-2965019 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References