Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2982006..2982654 Replicon chromosome
Accession NZ_CP041818
Organism Mycobacterium tuberculosis strain 4-0087P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ91_RS13895 Protein ID WP_003899414.1
Coordinates 2982006..2982329 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ91_RS13900 Protein ID WP_003899415.1
Coordinates 2982409..2982654 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ91_RS13865 2977329..2978327 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ91_RS13870 2978341..2978805 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ91_RS13875 2978793..2979044 + 252 WP_003908028.1 hypothetical protein -
FPJ91_RS13880 2979215..2980654 - 1440 WP_003899411.1 phage major capsid protein -
FPJ91_RS13885 2980662..2981195 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ91_RS13890 2981348..2981839 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ91_RS13895 2982006..2982329 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ91_RS13900 2982409..2982654 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ91_RS13905 2982651..2984078 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ91_RS13910 2984080..2984472 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ91_RS13915 2984469..2984729 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ91_RS13920 2984746..2985108 - 363 WP_003900543.1 hypothetical protein -
FPJ91_RS13925 2985111..2986238 - 1128 WP_003899420.1 site-specific integrase -
FPJ91_RS13930 2986383..2986610 - 228 WP_003899421.1 hypothetical protein -
FPJ91_RS13935 2986607..2986996 - 390 WP_003899422.1 hypothetical protein -
FPJ91_RS13940 2986902..2987174 + 273 WP_003900544.1 hypothetical protein -
FPJ91_RS13945 2987273..2987506 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2977329..2986238 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T131110 WP_003899414.1 NZ_CP041818:c2982329-2982006 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T131110 NZ_CP041818:c2982329-2982006 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT131110 WP_003899415.1 NZ_CP041818:c2982654-2982409 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT131110 NZ_CP041818:c2982654-2982409 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References