Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2189056..2189924 Replicon chromosome
Accession NZ_CP041817
Organism Mycobacterium tuberculosis strain 4-0096P6C4

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag FPJ92_RS10105 Protein ID WP_010886136.1
Coordinates 2189056..2189433 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag FPJ92_RS10110 Protein ID WP_003409886.1
Coordinates 2189475..2189924 (+) Length 150 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ92_RS10055 2184845..2185297 - 453 WP_003899095.1 lipoprotein -
FPJ92_RS10060 2185361..2185762 + 402 WP_003409869.1 hypothetical protein -
FPJ92_RS10065 2185755..2185937 - 183 WP_019250140.1 hypothetical protein -
FPJ92_RS10070 2186051..2186401 - 351 WP_003409871.1 hypothetical protein -
FPJ92_RS10075 2186412..2187314 - 903 WP_003899097.1 hypothetical protein -
FPJ92_RS10080 2187335..2187526 - 192 WP_003409876.1 hypothetical protein -
FPJ92_RS10085 2187527..2187823 - 297 WP_003409877.1 hypothetical protein -
FPJ92_RS10090 2188063..2188278 + 216 WP_003409878.1 antitoxin -
FPJ92_RS10095 2188275..2188586 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
FPJ92_RS10100 2188560..2189081 - 522 WP_003904745.1 hypothetical protein -
FPJ92_RS10105 2189056..2189433 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
FPJ92_RS10110 2189475..2189924 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
FPJ92_RS10115 2189921..2190466 + 546 WP_003409891.1 SecB-like chaperone -
FPJ92_RS10120 2190355..2190969 - 615 WP_003901296.1 hypothetical protein -
FPJ92_RS10125 2191018..2191314 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
FPJ92_RS10130 2191311..2191562 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
FPJ92_RS10135 2191549..2192043 + 495 WP_003899099.1 hypothetical protein -
FPJ92_RS10140 2192203..2192610 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
FPJ92_RS10145 2192614..2192886 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
FPJ92_RS10150 2192919..2194139 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-113)

Antitoxin

(44-91)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T131034 WP_010886136.1 NZ_CP041817:2189056-2189433 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T131034 NZ_CP041817:2189056-2189433 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT131034 WP_003409886.1 NZ_CP041817:2189475-2189924 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT131034 NZ_CP041817:2189475-2189924 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCATCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU


Antitoxin

Source ID Structure
PDB 5MTW
AlphaFold DB G0TLM0

References