Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2982591..2983239 Replicon chromosome
Accession NZ_CP041816
Organism Mycobacterium tuberculosis strain SEA00042P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ93_RS13895 Protein ID WP_003899414.1
Coordinates 2982591..2982914 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ93_RS13900 Protein ID WP_003899415.1
Coordinates 2982994..2983239 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ93_RS13865 2977914..2978912 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ93_RS13870 2978926..2979390 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ93_RS13875 2979378..2979629 + 252 WP_003908028.1 hypothetical protein -
FPJ93_RS13880 2979800..2981239 - 1440 WP_003899411.1 phage major capsid protein -
FPJ93_RS13885 2981247..2981780 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ93_RS13890 2981933..2982424 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ93_RS13895 2982591..2982914 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ93_RS13900 2982994..2983239 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ93_RS13905 2983236..2984663 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ93_RS13910 2984665..2985057 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ93_RS13915 2985054..2985314 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ93_RS13920 2985331..2985693 - 363 WP_003900543.1 hypothetical protein -
FPJ93_RS13925 2985696..2986823 - 1128 WP_003899420.1 site-specific integrase -
FPJ93_RS13930 2986968..2987195 - 228 WP_003899421.1 hypothetical protein -
FPJ93_RS13935 2987192..2987581 - 390 WP_003899422.1 hypothetical protein -
FPJ93_RS13940 2987487..2987759 + 273 WP_003900544.1 hypothetical protein -
FPJ93_RS13945 2987858..2988091 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2977914..2986823 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(33-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T130989 WP_003899414.1 NZ_CP041816:c2982914-2982591 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T130989 NZ_CP041816:c2982914-2982591 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130989 WP_003899415.1 NZ_CP041816:c2983239-2982994 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130989 NZ_CP041816:c2983239-2982994 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References