Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2749698..2750346 Replicon chromosome
Accession NZ_CP041815
Organism Mycobacterium tuberculosis strain SEA02010036P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ94_RS12720 Protein ID WP_003899414.1
Coordinates 2749698..2750021 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ94_RS12725 Protein ID WP_003899415.1
Coordinates 2750101..2750346 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ94_RS12690 2745021..2746019 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ94_RS12695 2746033..2746497 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ94_RS12700 2746485..2746736 + 252 WP_003908028.1 hypothetical protein -
FPJ94_RS12705 2746907..2748346 - 1440 WP_003901443.1 phage major capsid protein -
FPJ94_RS12710 2748354..2748887 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ94_RS12715 2749040..2749531 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ94_RS12720 2749698..2750021 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ94_RS12725 2750101..2750346 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ94_RS12730 2750343..2751770 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ94_RS12735 2751772..2752164 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ94_RS12740 2752161..2752421 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ94_RS12745 2752438..2752800 - 363 WP_003900543.1 hypothetical protein -
FPJ94_RS12750 2752803..2753930 - 1128 WP_003899420.1 site-specific integrase -
FPJ94_RS12755 2754075..2754302 - 228 WP_003899421.1 hypothetical protein -
FPJ94_RS12760 2754299..2754688 - 390 WP_003899422.1 hypothetical protein -
FPJ94_RS12765 2754594..2754866 + 273 WP_003900544.1 hypothetical protein -
FPJ94_RS12770 2754965..2755198 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2745021..2757017 11996


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T130918 WP_003899414.1 NZ_CP041815:c2750021-2749698 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T130918 NZ_CP041815:c2750021-2749698 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130918 WP_003899415.1 NZ_CP041815:c2750346-2750101 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130918 NZ_CP041815:c2750346-2750101 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References