Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2998487..2999135 Replicon chromosome
Accession NZ_CP041813
Organism Mycobacterium tuberculosis strain SEA07010354P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ96_RS14010 Protein ID WP_003899414.1
Coordinates 2998487..2998810 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ96_RS14015 Protein ID WP_003899415.1
Coordinates 2998890..2999135 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ96_RS13980 2993810..2994808 + 999 Protein_2757 tyrosine-type recombinase/integrase -
FPJ96_RS13985 2994822..2995286 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ96_RS13990 2995274..2995525 + 252 WP_003908028.1 hypothetical protein -
FPJ96_RS13995 2995696..2997135 - 1440 WP_003901443.1 phage major capsid protein -
FPJ96_RS14000 2997143..2997676 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ96_RS14005 2997829..2998320 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ96_RS14010 2998487..2998810 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ96_RS14015 2998890..2999135 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ96_RS14020 2999132..3000559 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ96_RS14025 3000561..3000953 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ96_RS14030 3000950..3001210 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ96_RS14035 3001227..3001589 - 363 WP_003900543.1 hypothetical protein -
FPJ96_RS14040 3001592..3002719 - 1128 WP_003899420.1 site-specific integrase -
FPJ96_RS14045 3002864..3003091 - 228 WP_003899421.1 hypothetical protein -
FPJ96_RS14050 3003088..3003477 - 390 WP_003899422.1 hypothetical protein -
FPJ96_RS14055 3003383..3003655 + 273 WP_003900544.1 hypothetical protein -
FPJ96_RS14060 3003754..3003987 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2993810..3002719 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T130807 WP_003899414.1 NZ_CP041813:c2998810-2998487 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T130807 NZ_CP041813:c2998810-2998487 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130807 WP_003899415.1 NZ_CP041813:c2999135-2998890 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130807 NZ_CP041813:c2999135-2998890 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References