Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2979329..2979977 Replicon chromosome
Accession NZ_CP041811
Organism Mycobacterium tuberculosis strain SEA08151P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag FPJ98_RS13870 Protein ID WP_003903987.1
Coordinates 2979329..2979652 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ98_RS13875 Protein ID WP_003899415.1
Coordinates 2979732..2979977 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ98_RS13840 2974652..2975650 + 999 WP_003908027.1 tyrosine-type recombinase/integrase -
FPJ98_RS13845 2975664..2976128 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ98_RS13850 2976116..2976367 + 252 WP_003908028.1 hypothetical protein -
FPJ98_RS13855 2976538..2977977 - 1440 WP_003901443.1 phage major capsid protein -
FPJ98_RS13860 2977985..2978518 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ98_RS13865 2978671..2979162 - 492 WP_193024166.1 phage terminase small subunit P27 family -
FPJ98_RS13870 2979329..2979652 - 324 WP_003903987.1 type II toxin-antitoxin system toxin Toxin
FPJ98_RS13875 2979732..2979977 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ98_RS13880 2979974..2981401 - 1428 WP_193024167.1 DUF3631 domain-containing protein -
FPJ98_RS13885 2981403..2981795 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ98_RS13890 2981792..2982052 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ98_RS13895 2982069..2982431 - 363 WP_003900543.1 hypothetical protein -
FPJ98_RS13900 2982434..2983561 - 1128 WP_031707873.1 site-specific integrase -
FPJ98_RS13905 2983706..2983933 - 228 WP_003899421.1 hypothetical protein -
FPJ98_RS13910 2983930..2984319 - 390 WP_003899422.1 hypothetical protein -
FPJ98_RS13915 2984225..2984497 + 273 WP_003900544.1 hypothetical protein -
FPJ98_RS13920 2984596..2984829 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2974652..2983561 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12353.82 Da        Isoelectric Point: 7.4705

>T130686 WP_003903987.1 NZ_CP041811:c2979652-2979329 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMMLGWHPYQFPDEPDSKQ

Download         Length: 324 bp

>T130686 NZ_CP041811:c2979652-2979329 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCTGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGATGCTCGGCTGGCATCCGTATCAGTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130686 WP_003899415.1 NZ_CP041811:c2979977-2979732 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130686 NZ_CP041811:c2979977-2979732 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References