130625

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2972667..2973315 Replicon chromosome
Accession NZ_CP041810
Organism Mycobacterium tuberculosis strain SEA08162P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPJ99_RS13885 Protein ID WP_003899414.1
Coordinates 2972667..2972990 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPJ99_RS13890 Protein ID WP_003899415.1
Coordinates 2973070..2973315 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPJ99_RS13855 2967990..2968988 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPJ99_RS13860 2969002..2969466 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPJ99_RS13865 2969454..2969705 + 252 WP_003908028.1 hypothetical protein -
FPJ99_RS13870 2969876..2971315 - 1440 WP_003899411.1 phage major capsid protein -
FPJ99_RS13875 2971323..2971856 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPJ99_RS13880 2972009..2972500 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPJ99_RS13885 2972667..2972990 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPJ99_RS13890 2973070..2973315 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPJ99_RS13895 2973312..2974739 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
FPJ99_RS13900 2974741..2975133 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPJ99_RS13905 2975130..2975390 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPJ99_RS13910 2975407..2975769 - 363 WP_003900543.1 hypothetical protein -
FPJ99_RS13915 2975772..2976899 - 1128 WP_003899420.1 site-specific integrase -
FPJ99_RS13920 2977044..2977271 - 228 WP_003899421.1 hypothetical protein -
FPJ99_RS13925 2977268..2977657 - 390 WP_003899422.1 hypothetical protein -
FPJ99_RS13930 2977563..2977835 + 273 WP_003900544.1 hypothetical protein -
FPJ99_RS13935 2977934..2978167 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2967990..2976899 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T130625 WP_003899414.1 NZ_CP041810:c2972990-2972667 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T130625 NZ_CP041810:c2972990-2972667 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130625 WP_003899415.1 NZ_CP041810:c2973315-2973070 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130625 NZ_CP041810:c2973315-2973070 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References