Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2189723..2190591 | Replicon | chromosome |
| Accession | NZ_CP041808 | ||
| Organism | Mycobacterium tuberculosis strain SEA09167P6C4 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | FPK01_RS10145 | Protein ID | WP_010886136.1 |
| Coordinates | 2189723..2190100 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | FPK01_RS10150 | Protein ID | WP_193019720.1 |
| Coordinates | 2190142..2190591 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FPK01_RS10095 | 2185512..2185964 | - | 453 | WP_003899095.1 | lipoprotein | - |
| FPK01_RS10100 | 2186028..2186429 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| FPK01_RS10105 | 2186422..2186604 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| FPK01_RS10110 | 2186718..2187068 | - | 351 | WP_003899096.1 | hypothetical protein | - |
| FPK01_RS10115 | 2187079..2187981 | - | 903 | WP_003899097.1 | hypothetical protein | - |
| FPK01_RS10120 | 2188002..2188193 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| FPK01_RS10125 | 2188194..2188490 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| FPK01_RS10130 | 2188730..2188945 | + | 216 | WP_003409878.1 | antitoxin | - |
| FPK01_RS10135 | 2188942..2189253 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPK01_RS10140 | 2189227..2189748 | - | 522 | WP_193019719.1 | hypothetical protein | - |
| FPK01_RS10145 | 2189723..2190100 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| FPK01_RS10150 | 2190142..2190591 | + | 450 | WP_193019720.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| FPK01_RS10155 | 2190588..2191133 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| FPK01_RS10160 | 2191022..2191636 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| FPK01_RS10165 | 2191685..2191981 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FPK01_RS10170 | 2191978..2192229 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| FPK01_RS10175 | 2192216..2192710 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| FPK01_RS10180 | 2192870..2193277 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| FPK01_RS10185 | 2193281..2193553 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FPK01_RS10190 | 2193586..2194806 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T130487 WP_010886136.1 NZ_CP041808:2189723-2190100 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T130487 NZ_CP041808:2189723-2190100 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16661.03 Da Isoelectric Point: 7.3597
>AT130487 WP_193019720.1 NZ_CP041808:2190142-2190591 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHGLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHGLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT130487 NZ_CP041808:2190142-2190591 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATGGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATGGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|