Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2962066..2962714 Replicon chromosome
Accession NZ_CP041806
Organism Mycobacterium tuberculosis strain SEA11020057P6C4

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag FPK03_RS13835 Protein ID WP_003899414.1
Coordinates 2962066..2962389 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag FPK03_RS13840 Protein ID WP_003899415.1
Coordinates 2962469..2962714 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPK03_RS13805 2957389..2958387 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
FPK03_RS13810 2958401..2958865 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
FPK03_RS13815 2958853..2959104 + 252 WP_003908028.1 hypothetical protein -
FPK03_RS13820 2959275..2960714 - 1440 WP_003899411.1 phage major capsid protein -
FPK03_RS13825 2960722..2961255 - 534 WP_003899412.1 HK97 family phage prohead protease -
FPK03_RS13830 2961408..2961899 - 492 WP_003900541.1 phage terminase small subunit P27 family -
FPK03_RS13835 2962066..2962389 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
FPK03_RS13840 2962469..2962714 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
FPK03_RS13845 2962711..2964138 - 1428 WP_003912825.1 DUF3631 domain-containing protein -
FPK03_RS13850 2964140..2964532 - 393 WP_003899417.1 DUF2742 domain-containing protein -
FPK03_RS13855 2964529..2964789 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
FPK03_RS13860 2964806..2965168 - 363 WP_003900543.1 hypothetical protein -
FPK03_RS13865 2965171..2966298 - 1128 WP_003899420.1 site-specific integrase -
FPK03_RS13870 2966443..2966670 - 228 WP_003899421.1 hypothetical protein -
FPK03_RS13875 2966667..2967056 - 390 WP_003899422.1 hypothetical protein -
FPK03_RS13880 2966962..2967234 + 273 WP_003900544.1 hypothetical protein -
FPK03_RS13885 2967333..2967566 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2957389..2966298 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T130383 WP_003899414.1 NZ_CP041806:c2962389-2962066 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T130383 NZ_CP041806:c2962389-2962066 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT130383 WP_003899415.1 NZ_CP041806:c2962714-2962469 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT130383 NZ_CP041806:c2962714-2962469 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References